Primary Bilateral Macronodular Adrenal Hyperplasia

• Koukoula, Chrysoula ^[1] ; Kyriakopoulos, Georgios ^[2] ; Tsagarakis, Stylianos ^[3] ; Argyro Vassiliadi, Dimitra ^[1]
  1. [1] Department of Endocrinology, Diabetes and Metabolism, European Reference Network on Rare Endocrine Conditions (ENDO-ERN), Evangelismos General Hospital, Athens, Attiki, Greece
  2. [2] Department of Pathology, Evangelismos General Hospital, Athens, Attiki, Greece
  3. [3] Private Practice, Athens, Attiki, Greece

  Mostrar afiliaciones +
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 55, Nº. 2, 2026, págs. 285-298
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Over the past few decades, PBMAH has transitioned from a rare subtype of adrenal Cushing syndrome to a heterogeneous, and genetically and biologically diverse entity. Once defined primarily by its morphological and hormonal features, PBMAH is now recognized as a spectrum of disorders arising from multiple, and sometimes coexisting, pathogenic mechanisms, including aberrant expression of G protein-coupled receptors, intra-adrenal ACTH production, and clonal genetic alterations consistent with