Bioprocess Engineering: Advances in Cell Culture Systems, Reactor Design, Scale-up Strategies, and Intensification Processes for the Production of Biological and Bioactive Compounds

Freddy Ednildon Bautista Vanegas; Jose Luis Diaz Guerrero; Ingrid Neysa Cabezas Soliz; Blas Apaza Huanca; Estefannie Eunice Valverde Fernández; Jhossmar Cristians Auza Santiváñez; Themis Karim Ocampo Gamboa; Rebeca Rocio Gomez Rosales; Luis Mariano Tecuatl Gómez; Pablo Carias; Ruben Marco Antonio Soliz Mendoza

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Bioprocess Engineering: Advances in Cell Culture Systems, Reactor Design, Scale-up Strategies, and Intensification Processes for the Production of Biological and Bioactive Compounds

Bautista-Vanegas , Freddy Ednildon ^[3] ; Diaz-Guerrero , Jose Luis ^[4] ; Cabezas-Soliz , Ingrid Neysa ^[5] ; Apaza-Huanca, Blas ^[5] ; Valverde Fernández, Estefannie Eunice ^[1] ; Auza-Santivañez , Jhossmar Cristians ^[5] ; Ocampo Gamboa, Themis Karim ^[6] ; Gomez Rosales, Rebeca Rocio ^[7] ; Tecuatl Gómez , Luis Mariano ^[8] ; Carías, Pablo ^[2] ; Soliz-Mendoza , Ruben Marco Antonio ^[9]
1. [1] Universidad Evangélica Boliviana
  
  Universidad Evangélica Boliviana
  
  Bolivia
2. [2] Universidad Nacional Autónoma de Honduras
  
  Universidad Nacional Autónoma de Honduras
  
  Honduras
3. [3] Kliniken Beelitz GmbH Neurologische Rehabilitationsklinik: Beelitz Heilstätten, Brandenburg, DE. Germany
4. [4] Seguro Social Universitario Tarija (SSUT). Servicio de Ecografía. Tarija, Bolivia
5. [5] Ministerio de Salud y Deportes. Instituto Académico Científico Quispe-Cornejo. La Paz, Bolivia
6. [6] Universidad de Aquino Bolivia (UDABOL). Santa Cruz, Bolivia
7. [7] Hospital Infanto Juvenil Menino de Jesus M. São Paulo, Brazil
8. [8] ISSSTE San José del Cabo. Universidad De Los Cabos. México
9. [9] Centro de Salud “San Juan Kenko”. Red de Salud Corea. La Paz, Bolivia
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Localización: SAP Biomedical & Chemical Engineering Innovation, ISSN-e 3125-2281, Nº. 3, 2024
Idioma: inglés
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Resumen
- Bioprocess engineering is undergoing an unprecedented transformation, driven by the growing demand for complex and bioactive biological products across diverse industries, from pharmaceuticals to food and energy. Recent advances have redefined the efficiency, scalability, and sustainability of biomanufacturing. Key elements of this evolution include the widespread adoption of single-use systems, the integration of automation and artificial intelligence (AI) for precise control and predictive optimization, and the fundamental shift toward continuous bioprocessing. These innovations not only reduce costs and production times but also improve product quality and consistency, enabling the manufacturing of personalized therapies and high-value compounds. Scaling strategies have diversified to include both scale-up and parallel expansion (scale-out), tailored to specific product needs. Together, these developments are laying the foundation for more agile, cost-effective, and environmentally responsible biomanufacturing, preparing the industry to address global challenges in health and sustainability.