Antibiotic prescribing and resistance patterns among patients admitted to tertiary care hospital with Urinary tract infections at United Arab Emirates (UAE).

Rawda Hassan; Yelly Oktavia Sari; Syed Wasif Gillani; Hassaan A. Rathore

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Antibiotic prescribing and resistance patterns among patients admitted to tertiary care hospital with Urinary tract infections at United Arab Emirates (UAE).

Hassan, Rawda ^[1] ; Sari, Yelly Oktavia ^[2] ; Gillani, Syed Wasif ^[1] ; Rathore, Hassaan Anwer ^[3]
1. [1] Gulf Medical University
  
  Gulf Medical University
  
  Emiratos Árabes Unidos
2. [2] Andalas University
  
  Andalas University
  
  Indonesia
3. [3] Qatar University
  
  Qatar University
  
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Localización: Pharmacy Practice (Granada), ISSN-e 1886-3655, Vol. 24, Nº. 1, 2026 (Ejemplar dedicado a: Jan-Mar)
Idioma: inglés
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Resumen
- Background: Urinary tract infections (UTIs) are among the most common bacterial infections, affecting individuals across all age groups. Gram-negative bacilli, especially E. coli, account for over 80% of acute UTI cases, while other pathogens like Staphylococcus saprophyticus, Klebsiella, Proteus, Pseudomonas, and Enterobacter are less common. Objectives: This study aimed to investigate the epidemiology of uropathogens and assess antimicrobial stewardship practices in the management of urinary tract infections (UTIs) at a tertiary care hospital. Methods: This retrospective study evaluated all adult patients diagnosed with UTIs over a defined time period. Microbiological data was collected to determine the prevalence of uropathogen species. Antimicrobial utilization patterns were analyzed, focusing on initial empiric use of broad-spectrum carbapenems (meropenem) and subsequent de-escalation to more targeted therapy. Results: A total of 124 UTI cases were included in this study. The Escherichia coli was the most prevalent uropathogen, isolated in the majority of UTI cases. Female patients exhibited a higher incidence of UTIs compared to male patients. Initial empiric use of meropenem, was observed in 31.4% of cases. De-escalation of antimicrobial therapy was achieved in 62.1% of cases. A high prevalence (12/16 cases – 75%) of ESBL-producing E. coli was found, which influences empiric therapy choices and de-escalation opportunities. Conclusion: The high prevalence of ESBL-producing E. coli and the relatively high rate of broad-spectrum antibiotic prescribing demonstrated the need for continued antimicrobial stewardship efforts to optimize empiric therapy and promote de-escalation strategies.