Combinatorial multiplicity of cardiometabolic and inflammatory markers in gum arabica modality of CKD CAM: Part 2

• Alshelleh, Sameeha ^[2] ; Suyagh, Maysa ^[1] ; Alhawari, Hussein ^[2] ; Bulatova, Nailya ^[1] ; Kasabri, Violet ^[1] ; Wahbeh, Ayman ^[2] ; Alawwa, Izzat ^[2] ; Oweis, Ashraf ^[3] ; Mustafa, Haneen ^[1]
  1. [1] University of Jordan

     University of Jordan

     Jordania

     
  2. [2] School of Medicine, University of Jordan and Jordan University Hospital, Amman, Jordan.
  3. [3] School of Medicine, Jordan University of Science and Technology and King Abdullah University Hospital, Ramtha, Jordan.

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• Localización: Pharmacy Practice (Granada), ISSN-e 1886-3655, Vol. 23, Nº. 3, 2025 (Ejemplar dedicado a: Jul-Sep)
• Idioma: inglés
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  • Aim: A combinatorial multiplicity of molecular blood markers were assessed using ELISA colorimetric determinations in this prospective cohort study of the impact of guar gum arabica (GA) use on kidney function parameters of chronic kidney disease (CKD) in consumers (cases) vs. non consumers (age- and CKD stage- matched controls). Results: Mean age of study participants was 68.12 (±SD 10) years with homogenous sex distribution in both study arms and comparable levels of eGFR, sCr, ESR, CRP, HbA1c, FPG, UA and fasting lipid profiling parameters (P value >0.05). Consistently in study population of recruits; mean CKD duration was 6.94 years (±SD 7.8) and CKD stage IV (37.6% of total study population) was of predominant incidence, followed by stages IIIa and IIIb (20.4% and 19.4%, respectively). Despite the negative glucosuria in 75% of CKD patients; hypertension (92.5%), dyslipidemia (64.8%) and diabetes mellitus (54.8%) were prevalent in a descending order of predominance. GA consumption mean duration was 1.3±1.1 (range 0.25-6) years with a mean dose of 1.7±1.0 (range 0.5-6) spoons per day. Remarkably plasma concentrations of resistin (P value =0.047), and nesfatin-1 in cases were substantially greater (P value =0.005) but obestatin (P value =0.018), kisspeptin (P value =0.006), and vascular endothelial growth factor (VEGF) (P value =0.003) were found of pronouncedly lower blood levels in cases in comparison to those of controls. Invariably, human asymmetric dimethylarginine (ADMA), zinc alpha 2-glycoprtein, alpha klotho, ghrelin, and C-reactive protein (CRP) lacked any significant discrepancies in plasma levels in cases vs. those of controls (P value >0.05). In CKD cases on GA modality, ghrelin had substantial inverse correlations with dialysis duration, FBS and uric acid in CKD cases. Pronounced proportional associations of sCr levels were found with ghrelin, hsCRP and resistin in the same pool of cases. eGFR disproportionally correlated with cases’ hsCRP and resistin. In GA-naïve-CKD controls; sCr related proportionally and significantly with asymmetric dimethylarginine (ADMA) and Zinc alpha 2-glycoprtein. Conclusively: interventional studies are much justifiably needed.