Effectiveness of topical intranasal curcumin in the experimentally induced allergic rhinitis model in rats (revised)

• Erbay Demir ^[2] ; Muhsin Koten ^[3] ; Fatma Elif Usturalı Keskin ^[1] ; Canan Eryıldız ^[1] ; Selis Gülseven Güven ^[1]
  1. [1] Trakya University

     Trakya University

     Turquía

     
  2. [2] Department of Otorhinolaryngology, Independent Investigator, Istanbul, Türkiye
  3. [3] Department of Otorhinolaryngology, Kirklareli Training and Research Hospital, Kırklareli, Türkiye

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 54, Nº. 2, 2026, págs. 135-142
• Idioma: inglés
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  • Curcumin, a flavonoid derived from turmeric, has demonstrated antioxidant, anti-inflammatory, and antiallergic effects. This study evaluated the therapeutic efficacy of intranasal curcumin in an allergic rhinitis (AR) rat model. Forty rats were randomized into four groups: a sham control, an AR model with no treatment (negative control), an AR model treated with intranasal mometasone furoate (positive control), and an AR model treated with intranasal curcumin. Allergic symptoms (sneezing, itching, nasal discharge) were evaluated by both unblinded and blinded observers. Serum Ovalbumin (OVA)-specific IgE levels were measured using ELISA. Nasal mucosal histopathology (edema, cilia loss, goblet cell hyperplasia, inflammation, eosinophilia) was assessed by light microscopy. Intranasal curcumin significantly improved histopathological findings and reduced allergic symptoms, with efficacy comparable to steroid treatment. It alleviates AR symptoms and inflammation, suggesting a promising, low-cost alternative for AR management.