A comparison of the effect of omega-3 alone versus omega-3/Vitamin D3 co-supplementation therapy on 25-hydroxyvitamin D levels in adults with vitamin D deficiency.

Beisan A. Mohammad; Ghaleb Ali Oriquat; Heba A. Khader; Husni Shukri Farah; Ahmad R. Alsayed; Jehad F. Alhmoud; Mohammad A. AL NAJJAR; Luai Hasoun; Shaimaa M. Abdelhalim; Shady H. Awwad; Mahmoud S Abu-Samak

Ayuda

A comparison of the effect of omega-3 alone versus omega-3/Vitamin D3 co-supplementation therapy on 25-hydroxyvitamin D levels in adults with vitamin D deficiency.

Mohammad, Beisan A. ^[3] ; Oriquat, Ghaleb Ali ^[4] ; Khader, Heba A ^[1] ; Farah, Husni Shukri ^[5] ; Ahmad R. Alsayed ^[6] ; Alhmoud, Jehad F. ^[2] ; AL-NAJJAR, Mohammad A. ^[7] ; Hasoun, Luai ^[6] ; Abdelhalim, Shaimaa M. ^[8] ; Awwad, Shady H. ^[9] ; Abu-Samak, Mahmoud S. ^[6]
1. [1] Hashemite University
  
  Hashemite University
  
  Jordania
2. [2] Jordan University of Science and Technology
  
  Jordan University of Science and Technology
  
  Jordania
3. [3] Pharmaceutical Sciences Department- PharmD Program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia.
4. [4] Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.
5. [5] Faculty of Allied Medical Sciences, Al- Ahliyya Amman University, Amman 19328, Jordan.
6. [6] Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11937, Jordan
7. [7] Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University, Amman, Kingdom of Jordan.
8. [8] Department of Pharmaceutical Sciences, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia.
9. [9] Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, Amman 11937, Jordan.
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Localización: Pharmacy Practice (Granada), ISSN-e 1886-3655, Vol. 23, Nº. 1, 2025 (Ejemplar dedicado a: Jan-Marz)
Idioma: inglés
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Resumen
- Background: Omega-3 fatty acid (n-3FA) supplementation may improve total hydroxyvitamin D (25OHD) levels in people with normal or low vitamin D levels. However, there was no agreement on the potential therapeutic benefit of n-3FA on vitamin D toxicity. Objective: The current randomized controlled clinical study (RCT) sought to determine if daily omega-3 fatty acid (n-3FA) supple-mentation affected 25-hydroxyvitamin D (25OHD) levels. Methods: One hundred and twenty Jordanians aged 22 to 55 were randomly allocated into three groups supplemented with the dose of 50,000 IU VD3 taken weekly (D3) alone, 300 mg n-3FA taken daily (n-3FA) alone, or their com-bination (50,000 IU VD3 taken weekly + 300 mg n-3FA taken daily (D+). In addition, fasting baseline and follow-up (ten weeks; eight weeks supplementation plus two weeks washout) of serum 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), calcium, and leptin were assayed. Results: The n-3FA supplementation significantly decreased mean serum 25OHD levels (11.97±4.6 vs 16.5±4.8, P<0.001) compared with their peers in the D3 group who showed a significant increase in 25OHD levels (41.15±11.7 vs 19.34±6.8, P<0.001). The follow-up PTH mean levels were pro-portionally accompanied by significant alterations of 25OHD levels in the two study groups. Conclusions: This novel RCT provides that eight weeks of n-3FA therapy significantly reduced 25OHD levels, which adverse effects may accompany vitamin D status and its health-related consequences, such as bone homeostasis, cardiovascular disease, and COVID-19 conditions.