Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats

• Autores: Emilia María Carmona Calero, Herminia Calixta Pérez González, I. Martínez-Peña Valenzuela, Ibrahim González Marrero, Carlos Gustavo Pérez García, Norberto Marrero Gordillo, José Carlos Ormazábal Ramos, Agustín Lorenzo Castañeyra Perdomo, Romualdo Ferres Torres
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 20, Nº. 1, 2005, págs. 135-138
• Idioma: inglés
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  • Summary. We studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using anti-angiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment. Histol Histopathol 20, 135-138 (2005)