Bone Health in Acromegaly

• Birtolo, Maria Francesca ^[1] ; Jaafar, Simona ^[1] ; Cristofolini, Giancomo ^[1] ; Mazziotti, Gherardo ^[1] ; Lania, Andrea Gerardo ^[1]
  1. [1] Humanitas University

     Humanitas University

     Rozzano, Italia

     
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 54, Nº. 4, 2025, págs. 637-647
• Idioma: inglés
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• Resumen

  • Skeletal fragility is a well-known complication of acromegaly closely related to hypersecretion of GH and IGF1, leading to an increased fracture risk. At diagnosis and during follow-up, the evaluation of bone status is mandatory; however, nowadays the management of acromegaly-related osteopathy is still controversial. In Fig. 1 we proposed a simplified algorithm to assess skeletal fragility in this clinical setting. As first step, all patients should be evaluated by qualitative and