Metastatic melanoma of the major salivary glands: a systematic review

• Pedro Henrique Rizzardi ^[1] ; Amanda de Farias Gabriel ^[1] ; Isabela Domingues Martins ^[2] ; Vinicius Coelho Carrard ^[5] ; Virgílio Gonzalez Zanella ^[6] ; Fábio Muradás Girardi ^[1] ; Marco Antonio Trevizani Martins ^[5] ; Vivian Petersen Wagner ^[3] ; Manoela Domingues Martins ^[1] ; Lauren Frenzel Schuch ^[4]
  1. [1] Universidade Federal do Rio Grande do Sul

     Universidade Federal do Rio Grande do Sul

     Brasil

     
  2. [2] Michigan State University

     Michigan State University

     City of East Lansing, Estados Unidos

     
  3. [3] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
  4. [4] Universidad de la República

     Universidad de la República

     Uruguay

     
  5. [5] DDS, PhD, Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul; Department of Oral Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
  6. [6] MDM, Department of Head and Neck Surgery, Hospital Santa Rita, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 30, Nº. 5 (September), 2025, págs. 736-744
• Idioma: inglés
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• Resumen

  • Metastatic melanoma of the major salivary gland has been rarely reported in the literature. Thus, the aim of this study was to integrate all data about the clinical, sociodemographic, histopathological, treatment, and follow-up characteristics of metastatic melanoma of the major salivary glands.

    Electronic searches were performed in five databases and the grey literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Case reports or case series describing metastatic melanoma of the major salivary gland without language or year of publication restriction were included.

    Twenty-five studies reporting 47 cases of metastatic melanoma were identified. The mean patient age at diagnosis was 56.321.5 years, mainly occurring in men (70.2%). The site of the primary melanoma was mostly in the head and neck region (65%) and the parotid (93.6%) was the most affected major salivary gland by metastatic lesions. Parotidectomy was the main treatment choice. The overall 1- and 5-year survival rates were 79% and 45%, respectively.

    Metastatic melanoma of the major salivary gland is an uncommon phenomenon involving a poor prognosis.