Nowadays, human infertility affects approximately 17.5% of the global population and in 50% of cases, it is due to a male factor. Furthermore, diagnostic tools for male infertility have many limitations, as they are not 100% effective and involve the destruction of the male gametes. Metabolic and lipidomic studies could be of great use for evaluating semen quality, allowing us to have a more comprehensive and integrated molecular characterization of the underlying causes of male infertility. Additionally, the identification of metabolic biomarkers in seminal fluid couldenable us to perform a diagnostic test on the same seminal sample without destroying the spermatozoa.
Gaur egun giza antzutasunak munduko biztanleriaren %17.5ari eragiten dio eta kasuen %50ak faktore maskulinoei lotuta daude. Horrez gain, gizonen antzutasuna aztertzeko tresna diagnostikoak mugatuak dira, ez baitira %100ean eraginkorrak, eta gameto maskulinoen suntsipena dakarte. Ildo horretan, azterketa metabolikoak eta lipidomikoak oso baliagarriak izan daitezke, bai semen-kalitatea ebaluatzeko, bai gizonen antzutasuna eragiten duten kausen karakterizazio integralagoa gauzatzeko maila molekularrean. Gainera, likido seminalean biomarkatzaile metabolikoak identifikatzeak aukera eman diezaguke semen-lagin berean proba diagnostiko bat gauzatzeko espermatozoideak suntsitu gabe.
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