Metastasis of oncocytic thyroid carcinoma in the mandibular condyle: an exceptional localization

• Noemí Vieira-Sebe ^[1] ; Fernando Almeida-Parra ^[1] ; Álvaro Ranz-Colio ^[1] ; Esther Moreno-Moreno ^[2] ; Julio Acero-Sanz ^[1]
  1. [1] Department of Oral and Maxillofacial Surgery, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain; Department of Oral and Maxillofacial Surgery, Puerta de Hierro Majadahonda University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain; Faculty of Medicine, Alcalá University, Alcalá de Henares, Spain
  2. [2] Department of Pathology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), Madrid; Faculty of Medicine, Alcalá University, Alcalá de Henares, Spain
• Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 17, Nº. 5 (May), 2025, págs. 614-618
• Idioma: inglés
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• Resumen

  • Oncocytic thyroid carcinoma, previously known as Hürthle cell carcinoma, is a well-differentiated neoplasm accounting for 3-5% of malignant thyroid tumors. This type of carcinoma exhibits aggressive behavior with a propensity for lymphovascular invasion and distant metastases.

    To present an unusual clinical case of oncocytic thyroid carcinoma metastasis to the right mandibular condyle, highlighting its surgical management and clinical significance.

    An 86-year-old woman with a history of oncocytic thyroid carcinoma treated with total thyroidectomy and radioactive iodine in 2019. During follow-up, elevated thyroglobulin levels were detected, and a PET-CT scan revealed uptake in the right mandibular condyle. The lesion was confirmed by magnetic resonance imaging and surgical biopsy and was treated with a right condylectomy. Histopathological analysis revealed bone infiltration by oncocytic carcinoma. The patient had a favorable postoperative course, with undetectable serum thyroglobulin levels after surgery.

    Bone metastases from oncocytic carcinoma are rare, with the lungs being the most common metastatic site. To our knowledge, this is the second reported case of mandibular metastasis and the first involving the mandibular condyle, underscoring the importance of radical surgical intervention and a multidisciplinary approach in such cases.

    This case highlights the aggressive nature of oncocytic thyroid carcinoma and the importance of early diagnosis and personalized treatment to improve the prognosis of bone metastases.