Predictive value of prognostic nutritional index as prognostic biomarkers in patients with lymphoma: a systematic review and meta‑analysis

• Xuan Liu ^[1] ; Yuqing Duan ^[1] ; Yixian Wang ^[1] ; Xin Zhang ^[1] ; Hongbo Lv ^[1] ; Qiong Li ^[1] ; Na Qiao ^[1] ; Hengyu Meng ^[1] ; Linwei Lan ^[1] ; Xiumin Liu ^[2] ; Xin Liu ^[1]
  1. [1] Jilin University

     Jilin University

     China

     
  2. [2] Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 3, 2025, págs. 1274-1287
• Idioma: inglés
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• Resumen

  • Background Several research have indicated the signifcant potential of the Prognostic Nutritional Index (PNI) as a prognostic biomarker in lymphoma patients. However, there is some inconsistency in the fndings of a few studies. Hence, to ofer a thorough evaluation of the predictive signifcance of PNI in lymphoma patients, we performed a meta-analysis to examine the prognostic value of PNI for survival outcomes in lymphoma patients.

    Methods We conducted a comprehensive search for pertinent works published up until December 2023 in databases such as PubMed, EMBASE, Cochrane Library, and Web of Science. We obtained hazard ratio (HR) data related to survival outcomes and computed aggregated HRs with their corresponding 95% confdence intervals (CIs) to evaluate the correlation between PNI and both overall survival (OS) and progression-free survival (PFS) in lymphoma patients.

    Results By analyzing data from 1260 patients in 28 studies, we found that PNI levels were associated with prognosis in lymphoma patients. High PNI levels predicted that patients had longer OS (HR: 0.46, 95% CI 0.37–0.58, P<0.05) and better PFS (HR: 0.56, 95% CI 0.45–0.70, P<0.05). Subgroup analyses showed that the predictive ability of PNI for patient prognosis may difer depending on the type of lymphoma. In addition, we found that the critical PNI value had greater predictive potential at 40–45 and above 45.

    Conclusion Our study suggests a strong association between PNI and prognostic outcomes in lymphoma patients, indicating that PNI holds substantial prognostic value in this population.