Clinicopathological and prognostic value of tertiary lymphoid structures in lung cancer: a meta‑analysis
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Luyao Ma [1] ; Xiaobing Qin [1] ; Aoyang Yu [1] ; Haonan Liu [1] ; Di Pan [1] ; Ying Gao [1] ; Zichen Wu [1] ; Zihan Chen [1] ; Zhengxiang Han [1]
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[1] The Afliated Hospital of Xuzhou Medical University, Quanshan District, No. 99 West Huaihai Road, Xuzhou, Jiangsu, China
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 3, 2025, págs. 1092-1104
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Objective The purpose of this meta-analysis was to examine the clinicopathological and prognostic signifcance of tertiary lymphocytic infltrates in lung cancer.
Method A systematic search was performed in many databases, including PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wangfangdate, and CBM, up until January 2024. We calculated the hazard ratio (HR), odds ratios (OR), and confdence interval (CI), and accomplished this meta-analysis with Stata 15 software.
Result 14 studies, including 3101 patients, were subjected to analysis. High TLS detection was associated with a longer OS (HR=0.545, 95% CI: 0.359–0.827, p=0.004), DFS (HR=0.431, 95% CI: 0.350–0.531, p<0.001), and RFS (HR=0.430, 95% CI: 0.325–0.569, p<0.001). Meanwhile, it was observed that a higher detection of TLS was signifcantly correlated with the administration of adjuvant chemotherapy (OR=1.505, 95% CI: 1.017–2.225, p=0.041). Not only that, but there was a higher occurrence of signifcantly elevated TLS detection in the early N stages (N=0) compared to the advanced N stages (N=1, 2, and 3) (OR=1.604, 95% CI: 1.021–2.521, p=0.04).
Conclusion Elevated detection of TLS has been observed to be correlated with extended OS, DFS, and RFS in cases of lung cancer. This fnding suggests that TLS could potentially serve as a valuable prognostic biomarker for lung cancer.
