Evaluation of normal tissue complications in breast cancer re‑irradiation: a meta‑analysis study

• A. Amraee ^[2] ; Y. Mokhayeri ^[3] ; M. Gholami ^[2] ; S. Resane ^[2] ; M. R. Evazi ^[1] ; M. Abbasi ^[2] ; M. Sadr ^[2] ; Sh. Shamsi ^[2] ; P. Tayebzadeh ^[2] ; A. Jahani ^[2] ; L. Darvish ^[1]
  1. [1] Hormozgan University of Medical Sciences

     Hormozgan University of Medical Sciences

     Irán

     
  2. [2] Department of Medical Physics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. [3] Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 3, 2025, págs. 805-815
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background In recent years, evidence has accumulated that a second method of conserving the breast from cancer with reirradiation as part of treatment may be feasible and safe. Many oncologists are skeptical of breast re-irradiation due to concerns about late complications, so access to quantitative data on the prevalence of breast re-irradiation complications is very important. In this meta-analysis, we determine the prevalence of complications in normal tissue after breast re-irradiation.

    Materials and methods A search was done to recognize qualifed studies using EMBASE, MEDLINE, PUBMED, Google Scholar, and Cochrane Collaboration Library electronic databases from 2000 to 2023. In total, ten primary studies were applied in this meta-analysis to estimate the prevalence of complications of disorders, skin fbrosis, and chest pain. Heterogeneity was investigated using the I2 index and the meta-regression to evaluate variables suspected of causing heterogeneity.

    Statistical analysis and synthesis were performed using Stata 17.

    Results The average dose received by patients who underwent radiation therapy in two stages was 100.32 Gy, and in these patients, the prevalence of skin fbrosis and disorders was 47% (95% CI 71–22%; I2=96.76%, P<0.001) and the prevalence of chest pain was 35% (95% CI 68–8%; I2=98.13%, P<0.001).

    Conclusions There is little clinical information about the incidence of complications in breast re-irradiation therapy. This meta-analysis presents the prevalence of complications after breast re-irradiation to help radiation oncologists and physicists make better decisions.