Sensitization profile of Thai children with fish allergy

• Supaluk Tangvalelerd ^[1] ; Surapon Piboonpocanun ^[2] ; Unchalee Raungsirarak ^[1] ; Manaporn Sirichuwong ^[1] ; Pakit Vichyanond ^[3] ; Punchama Pacharn ^[1]
  1. [1] Mahidol University

     Mahidol University

     Tailandia

     
  2. [2] Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand
  3. [3] Samitivej Allergy Institute, Samitivej Thonburi Hospital, Bangkok, Thailand

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 53, Nº. 2, 2025, págs. 108-112
• Idioma: inglés
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  • Introduction: Fish allergies are common food allergies, and in Thailand, the prevalence of fish allergies in children ranges from 0.29% to 1.1%. Common fish allergens include parvalbumin, enolase, and aldolase.Method: This cross-sectional study included children with immunoglobulin E (IgE)-mediated fish allergies. The diagnosis was based on clinical history with a positive skin prick test (SPT) and/or specific IgE (sIgE). Serum IgE binding profiles to allergens in fish extracts were analyzed.Result: Eleven children, with a median age of 3 years, were recruited; the median age of onset was 1.25 years. Cutaneous symptoms were the most frequent clinical manifestation (63.6%). Tilapia and catfish were the most common triggers. All participants showed positive SPT and/or sIgE results for fish species. The immunoblot analysis revealed IgE binding to 40–50 kDa protein in all participants, while only seven participants (63.6%) showed IgE binding to the 11 kDa protein.Conclusion: Tilapia and catfish are the most common triggers of fish allergies in Thai children. The 40–50 kDa proteins were identified as a major fish allergen in tested cohort