The Magnitude of the Blood Acid–Base Response, but Not Time to Peak, Is Reliable Following the Ingestion of Acute, Individualized Sodium Citrate

Daniel J. Tinnion; Ben Dobson; Nathan Hilton; Lars R. McNaughton; Andy S. Sparks

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The Magnitude of the Blood Acid–Base Response, but Not Time to Peak, Is Reliable Following the Ingestion of Acute, Individualized Sodium Citrate

Daniel J. Tinnion ^[1] ; Ben Dobson ^[2] ; Nathan Hilton ^[3] ; Lars R. McNaughton ^[2] ; Andy S. Sparks
1. [1] Manchester Metropolitan University
  
  Manchester Metropolitan University
  
  Reino Unido
2. [2] Edge Hill University
  
  Edge Hill University
  
  West Lancashire District, Reino Unido
3. [3] Medical School, Edge Hill University, Ormskirk, United Kingdom
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Localización: International journal of sport nutrition and exercise metabolism, ISSN 1526-484X, ISSN-e 1543-2742, Vol. 35, Nº. 2, 2025, págs. 131-139
Idioma: inglés
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Resumen
- Enhanced buffering capacity following sodium citrate (SC) ingestion may be optimized when subsequent exercise commences at individual time-to-peak (TTP) alkalosis (blood pH or bicarbonate concentration [HCO3−]). While accounting for considerable interindividual variation in TTP (188–300 min), a reliable blood alkalotic response is required for practical use. This study evaluated the reliability of blood pH, HCO3−, and sodium (Na+) following acute SC ingestion. Fourteen recreationally active males ingested 0.4 or 0.5 g/kg body mass (BM) of SC on two occasions each and 0.07 g/kg BM of sodium chloride (control) once. Blood pH and HCO3− were measured for 4 hr postingestion. Blood pH and HCO3− displayed good reliability following 0.5 g/kg BM SC (r = .819, p = .002, standardized technical error [sTE] = 0.67 and r = .840, p < .001, sTE = 0.63, respectively). Following 0.4 g/kg BM SC, blood HCO3− retained good reliability (r = .771, p = .006, sTE = 0.78) versus moderate for blood pH (r = .520, p = .099, sTE = 1.36). TTP pH was moderately reliable following 0.5 (r = .676, p = .026, sTE = 1.05) and 0.4 g/kg BM SC (r = .679, p = .025, sTE = 0.91) versus poor for HCO3− following 0.5 (r = .183, p = .361, sTE = 5.38) and 0.4 g/kg BM SC (r = .290, p = .273, sTE = 2.50). Although the magnitude of (and displacement in) blood alkalosis, particularly HCO3−, appears reliable following potentially ergogenic doses of SC, strategies based on individual TTP cannot be recommended.