Journal of Pharmacology and Experimental Therapeutics

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  Año 2004, Vol. 310, Número 2

  • A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia

    A. Iwashita

    págs. 425-436

    

  • Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro^5^8^6

    E. Y. Zhang

    págs. 437-445

    

  • Imidazoline Receptors but Not alpha~2-Adrenoceptors Are Regulated in Spontaneously Hypertensive Rat Heart by Chronic Moxonidine Treatment

    J. Gutkowska, S. Mukaddam-Daher, R. El-Ayoubi, A. Menaouar

    págs. 446-451

    

  • Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation

    F. J. Tamarkin, W. S. Kang

    págs. 452-458

    

  • Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter through Phosphorylation during in Vitro Stroke Conditions and Nicotine Exposure

    T. J. Abbruscato

    págs. 459-468

    

  • Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1

    D. J. Murry, Zejin Sun, S. P. Sanghani

    págs. 469-476

    

  • Role of Adenosine A~1 Receptor in the Regulation of Gastrin Release

    L. Yip, H. C. H. Leung

    págs. 477-487

    

  • Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model

    J. F. Hess, R. W. Ransom

    págs. 488-497

    

  • Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor

    C.-Y. Xiao

    págs. 498-504

    

  • Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75^N^T^R Interactions in the Presence of TrkA

    A. Colquhoun, G. M. Lawrance, I. L. Shamovsky

    págs. 505-511

    

  • Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury

    S. E. Welty, W. Jiang, X. I. Couroucli

    págs. 512-519

    

  • A c-Jun NH~2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells

    A. Masamune

    págs. 520-527

    

  • Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor

    D. E. Brobst

    págs. 528-535

    

  • Regulation of Choline Transporter Surface Expression and Phosphorylation by Protein Kinase C and Protein Phosphatase 1/2A

    J. Gates, S. M. Ferguson

    págs. 536-545

    

  • Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques

    C. Y. Lin, B. Boland

    págs. 546-554

    

  • The Nitric Oxide-Releasing Naproxen Derivative Displays Cardioprotection in Perfused Rabbit Heart Submitted to Ischemia-Reperfusion

    B. Manfredi, G. Rossoni, P. Del Soldato

    págs. 555-562

    

  • Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-alpha-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)

    D. Kowal, L. Sun, R. Simon, D. Chiu, M. Smeyne, R. S. Zukin

    págs. 563-570

    

  • Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans

    N. Helsby, B. D. Palmer, J. Lu

    págs. 571-577

    

  • Effects of the Potential Antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone Monomethanesulfonate] a Combined sigma and 5-HT~1~A Ligand: Modulation of Neuronal Activity in the Dorsal Raphe Nucleus

    J. E. Bermack

    págs. 578-583

    

  • Abolition of Valproate-Derived Choleresis in the Mrp2 Transporter-Deficient Rat

    A. W. E. Wright, R. G. Dickinson

    págs. 584-588

    

  • Metallothionein Mediates the Level and Activity of Nuclear Factor kappaB in Murine Fibroblasts

    W. A. Kennette, H. L. Butcher

    págs. 589-598

    

  • Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome

    C. Antzelevitch, Lin Wu, L. Belardinelli, J. C. Shryock

    págs. 599-605

    

  • Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or kappa-Opioid Receptor Stimulation on Ca^2^+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults

    K. W. L. Kam, Jing Liu

    págs. 606-613

    

  • Metformin Causes Reduction of Food Intake and Body Weight Gain, and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats

    T. Inoue, K. Yamazaki, N. Yasuda, T. Nagakura

    págs. 614-619

    

  • 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB~1/CB~2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects

    D. Denzer, E. Reissmueller, J. De Vry

    págs. 620-632

    

  • Structural Features of the Botulinum Neurotoxin Molecule That Govern Binding and Transcytosis across Polarized Human Intestinal Epithelial Cells

    A. B. Maksymowych

    págs. 633-641

    

  • Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I~2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues

    T. D. Warner, I. Vojnovic, F. Giuliano

    págs. 642-647

    

  • Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice

    H. Sasabe

    págs. 648-655

    

  • UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver

    M. H. Court

    págs. 656-665

    

  • Different Regulation of Human delta-Opioid Receptors by SNC-80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Endogenous Enkephalins

    I. Lecoq, P. Jauzac, S. Allouche, N. Marie

    págs. 666-677