Clinical & translational oncology

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  Año 2026, Vol. 28, Número 2

  • REVIEW ARTICLE

    • LncRNAs signatures in gynecological cancers: ovarian and endometrial cancers

      Salsabeel Elkholey, Yahia Elgharib, Raafat El Awady, Ekram Saleh

      • Resumen

      págs. 387-403

      

    • Single-cell sequencing: accurate disease detection

      XiaoQin Wang, NianNian Li, Wei Wang, Bing Liu

      • Resumen

      págs. 404-423

      

    • Genetic landscape of cancer: mechanisms, key genes, and therapeutic implications

      Arun Karnwal, Joydeep Dutta, Aqueel Ur Rehman, Abdel Rahman Mohammad Said Al Tawaha, Natalia Nesterova

      • Resumen

      págs. 424-445

      

    • Molecular pathways and targeted therapies in colorectal liver metastasis: from bench to bedside

      Feng Liu, Yue-Chen Zhao, Yan Jiao

      • Resumen

      págs. 446-450

      

  • CLINICAL GUIDES IN ONCOLOGY

    • SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2025)

      María José Safont, Fernando Losa Gaspà, Encarnación González Flores, María Luisa Limón, José Luis Manzano Mozo, María Carmen Riesco Martínez, María del Rosario Vidal Tocino, Vicente Alonso Orduña, Elena Asensio Martínez, Ruth Vera García

      • Resumen

      págs. 451-462

      

  • RESEARCH ARTICLE

    • Development and validation of a transformer-based deep learning model for predicting distant metastasis in non-small cell lung cancer using 18FDG PET/CT images

      Na Hu, Yunpeng Luo, Maowen Tang, Shengmei Yuan, Fangyan Li, Pinggui Lei, Gang Yan

      • Resumen

      págs. 463-473

      

    • Use of PD-1/PD-L1 inhibitors in non-small cell lung cancer in elderly patients: a meta-analysis and systematic review of randomized clinical trials

      Ana Paula Bedin, Gabriela de Castro Neves Carmo Maffezolli, Luis Henrique Rios Moreira Rego, Maria Isadora Rodrigues Carlos, Pedro Henrique Albuquerque da Silva, Francisco Cezar Aquino de Moraes

      • Resumen

      págs. 474-483

      

    • PD-L1 expression scoring using artificial intelligence algorithms in non-small cell lung cancer harbouring ROS1 fusions: potential clinical-biological significance

      Luis Fernando García, E. Conde Gallego, Susana Hernández, Marta Alonso, Daniel Curto, Manuel Dómine Gómez, Federico Rojo, Javier Freire, José Javier Gómez Román, Antonio Calles, María Cebollero, José Luis González Larriba, Melchor Saiz, Isabel Esteban Rodríguez, Laura Gutiérrez, Fernando López Ríos, Javier de Castro Carpeño

      • Resumen

      págs. 484-493

      

    • Real-world clinical experience with osimertinib in advanced EGFR-mutated non-small cell lung cancer

      María Carmen Areses Manrique, Luis León Mateos, Sofía Silva Díaz, Ana Alonso, Martin Lázaro Quintela, Natalia Fernández Núñez, Francisco Javier Afonso Afonso, Pablo Freijido Álvarez, Manuel Fernández Bruno, Soledad Cameselle Garcia, Clara González Ojea, Gerardo Huidobro Vence, Blanca Távara Silva, Carme García Lorenzo, Javier Álvarez, Patricia Cordeiro González, Jesús García Mata, Cristina Azpitarte Raposeiras, Luis Ruiz de Almirón Lomo, Víctor Cebey López, Joaquín Mosquera Martínez, J. García González, Lucía Santomé Couto, Margarita Amenedo Gancedo, José Luis Fírvida Pérez

      • Resumen

      págs. 494-503

      

    • Cost-effectiveness of socazolimab plus chemotherapy vs. standard chemotherapy for first-line treatment of extensive-stage small cell lung cancer: a U.S. and China perspective

      Wenwang Lang, Jiangbo Wang, Haiqing Zhao, Yulong He, Qinling Jiang, Qi Ai, Ming Ouyang

      • Resumen

      págs. 504-518

      

    • Genomic insights on lung cancer risk: identifying new variants in Amazonian indigenous populations

      Bruno Melo Fernandes, Ana Caroline Alves da Costa, Natasha Monte, Kaio Evandro Cardoso Aguiar, Marcella Oliveira Monte Santo, Juliana Carla Gomes Rodrigues, Esdras Edgar Batista Pereira, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Ândrea Ribeiro dos Santos, André Maurício Ribeiro dos Santos, Rommel Mario Rodríguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos

      • Resumen

      págs. 519-526

      

    • Exploratory evaluation of CA 15-3 × NLR score for predicting pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy

      Emine Bihter Eniseler, Bartu Çetin, Ferhat Ekinci, Atike Pınar Erdogan, Mustafa Sahbazlar

      • Resumen

      págs. 527-532

      

    • Correlation of HER2 levels expression through HER2 mRNA PCR vs immunohistochemistry (IHC) in hormone receptor positive (HR+)/HER2 negative (HER2−) early breast cancer

      Alfonso López de Sá, Julia Tejerina Peces, Marta Amann, Pablo Ballestín, Beatriz González, Alejandro Pascual, C. Díaz del Arco, Vanesa García Barberán, Mateo Paz Cabezas, Alicia De Luna, José Ángel García Sáenz

      • Resumen

      págs. 533-540

      

    • Hotspots and future trends of male breast cancer: a global perspective

      Jie Hou, Hui Feng, Minheng Zhang, Dayi Wang, Haixia Fan

      • Resumen

      págs. 541-556

      

    • Multi-omics characterization of cachexia-related genes reveals prognostic signatures and immune landscape in breast cancer

      Siyu Wang, Hongxia Zhu, Wendi Zhan, Bo Hao, Zhuo Li, Taolan Zhang

      • Resumen

      págs. 557-574

      

    • Overexpression of cat eye syndrome chromosome region, candidate 2 in esophageal squamous carcinoma cell promotes tumor aggressiveness by facilitating NF-κB signaling and inhibition of p53-associated apoptosis

      Haote Zhu, Mitsuro Kanda, Dai Shimizu, Yusuke Sato, Tuvshin Bayasgalan, Mohammad Hussain Hamrah, Flor Esther Garza Martínez, Takahiro Shinozuka, Shinichi Umeda, Hideki Takami, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yasuhiro Kodera, Kotaro Aoki

      • Resumen

      págs. 575-588

      

    • Real-world management and outcomes of patients with hepatocellular carcinoma treated with systemic therapy in Spain: a patient cohort from the RETUD gastrointestinal registry

      Carlos López López, Eva Martínez de Castro, Ana Fernández Montes, Encarnacion Jiménez, Sandra López Peraita, Ruth Vera García, Paula Cerda, Mariona Calvo Campos, Beatriz García Paredes, Miriam Lobo de Mena, Adelaida la Casta Muñoa, Javier Gallego Plazas, Jorge Adeva, Juana María Cano Cano, Ana Ruiz Casado, María del Rosario Vidal Tocino, T. García García, Roberto Pazo Cid, Mercedes Rodríguez Garrote, Javier Sastre Valera

      • Resumen

      págs. 589-600

      

    • Prognostic significance of systemic immune-inflammation index in hepatocellular carcinoma: a meta-analysis

      Zhi Li, Juan Luo, Lihua Peng, Bangqiang Wu, Zebo Yu

      • Resumen

      págs. 601-616

      

    • Definition of lines of treatment in metastatic colorectal cancer: a Delphi consensus

      Pilar García Alfonso, Julia Alcaide García, Enrique Aranda Aguilar, Elena Élez Fernández, Ana Fernández Montes, Ignacio García Escobar, Cristina Grávalos Castro, Ignacio Matos García, Clara Montagut, Cristina Santos Vivas, Javier Sastre Valera, Noelia Tarazona Llavero, P. Jiménez Fonseca

      • Resumen

      págs. 617-624

      

    • Prognostic significance of DNA ploidy, stroma fraction, and nucleotyping in stage IIIb colon cancer and their implications for adjuvant chemotherapy

      Weili Zhang, Yuxin Gu, Xiajuan Xue, Xudan Li, Weifeng Wang, Ruowei Wang, Jiahua He, Weihao Li, Yue Xing, Yuguang Lin, Jianhong Peng

      • Resumen

      págs. 625-634

      

    • Dynamic blood-based biomarkers predict early response to ipilimumab and nivolumab in advanced melanoma

      Gökhan Şahin, Caner Acar, Haydar Çağatay Yüksel, Salih Tunbekici, Fatma Pinar Açar, Gülçin Çelebi, Burçak Karaca

      • Resumen

      págs. 635-644

      

    • Poor efficacy of anti PD-1 antibody based immunotherapy in patients with acral melanoma: results from the Spanish Melanoma Group (GEM) registry

      María González Cao, Miguel Ángel Berciano Guerrero, Eva Muñoz Couselo, José Luis Manzano Mozo, Pablo Cerezuela Fuentes, Guillermo Crespo Herrero, Ainara Soria, Pablo Ayala de Miguel, Lourdes Gutiérrez Sanz, Carlos Aguado de la Rosa, Almudena García Castaño, Teresa Puértolas Hernández, E. Espinosa Arranz, Javier Medina, Lorena Bellido, Alfonso Berrocal Jaime, Margarita Majem, R. Lopez Castro, Luis Antonio Fernández Morales, Francisco García, María Rodríguez de la Borbolla, Salvador Martín Algarra, Iván Márquez Rodas

      • Resumen

      págs. 645-653

      

    • LC3 and beclin-1 immunohistochemical and gene expressions in bladder cancer

      Samia Hussein, Ahmad Barakat Waley, Heba Mahmoud Abdelgeleel, Sara Fouad Saadawy, Sara Mohammed Ibrahim, Mohammed Hemeda, Reham Sameh

      • Resumen

      págs. 654-662

      

    • ERG expression is not predictive of outcome in patients with intermediate- and high-risk localized prostate cancer treated with combined androgen blockade and radiotherapy

      I. Henríquez, Bárbara Malave, Gemma Benítez Gabella, David Parada, Marta Canela, Raquel García Pablo, Rocío Benavides, Francesc Rius, Meritxell Arenas Prat

      • Resumen

      págs. 663-671

      

    • Serum response factor as a prognostic indicator of angiogenesis and early recurrence in Glioblastoma: a retrospective immunohistochemical study

      Bo Tan, Yaohui Huang, Tao Chen, Peng Song, Shuangyin He, Xiaohong Yin

      • Resumen

      págs. 672-681

      

    • Plasma lipidomics profiling to identify signatures of pediatric medulloblastoma

      Zhengyuan Shi, Chunjing Yang, Xiqiao Xu, Wanshui Wu, Li Bao

      • Resumen

      págs. 682-688

      

    • Unmasking risk in low-suspicion thyroid nodules: clinical and sonographic predictors of malignancy in TIRADS 3, a retrospective single-center study

      Dayana Torres Cuenca, Juan Eduardo Ortiz, Fabricio González-Andrade

      • Resumen

      págs. 689-700

      

    • Clinical value of ENO2 in serum extracellular vesicles for the diagnosis and prognosis of diffuse large B-cell lymphoma patients

      Ruiyu Yang, Yimin Hu, Qingguo Liu, Pingping Huang

      • Resumen

      págs. 701-710

      

  • BRIEF RESEARCH ARTICLE

    • Prognostic value of circulating HER2 extracellular domain in patients with HER2-positive metastatic breast carcinoma treated with TDM-1 (trastuzumab emtansine)

      Roman Vion, Céline Calbrix, Anca Berghian, Emilie Lévêque, Maxime Fontanilles, Cédric Paquin, Philippe Ruminy, Jean Rouvet, Marianne Leheurteur, Nathalie Olympios, Vinciane Rainville, Frédéric Di Fiore, Florian Clatot

      • Resumen

      págs. 711-718

      

    • A world map of air pollution and EGFR-mutant prevalence

      Leonardo Rojas, Guillermo Villacampa, Daniel Shao Weng Tan, Óscar Arrieta, Jairo Zuluaga, Andrés Felipe Cardona

      • Resumen

      págs. 719-725