Journal of Pharmacology and Experimental Therapeutics

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  Año 2006, Vol. 319, Número 3

  • A Death-Promoting Role for Extracellular Signal-Regulated Kinase

    S. Zhuang, R. G. Schnellmann

    págs. 991-1210

    

  • R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation

    S. Braselmann

    págs. 998-1042

    

  • Acetylcholine Release at Neuromuscular Junctions of Adult Tottering Mice Is Controlled by N- (Ca~v2.2) and R-Type (Ca~v2.3) but Not L-Type (Ca~v1.2) Ca^2^+ Channels

    W. D. Atchison, N. E. Pardo, R. K. Hajela

    págs. 1009-1020

    

  • Altered Calcium/Calmodulin Kinase II Activity Changes Calcium Homeostasis That Underlies Epileptiform Activity in Hippocampal Neurons in Culture

    S. N. Haider, D. S. Carter

    págs. 1021-1050

    

  • Differential Responses of Corticotropin-Releasing Hormone Receptor Type 1 Variants to Protein Kinase C Phosphorylation

    D. Markovic, N. Papadopoulou

    págs. 1032-1080

    

  • Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis

    A.-M. Pulichino

    págs. 1043-1394

    

  • Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-alpha

    J. LoVerme

    págs. 1051-1095

    

  • Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation

    J. Moungjaroen

    págs. 1062-1152

    

  • Coadministration of Sorafenib with Rottlerin Potently Inhibits Cell Proliferation and Migration in Human Malignant Glioma Cells

    E. P. Jane, D. R. Premkumar

    págs. 1070-1181

    

  • Calcium Channel Blocker Azelnidipine Reduces Glucose Intolerance in Diabetic Mice via Different Mechanism Than Angiotensin Receptor Blocker Olmesartan

    M. Iwai, H.-S. Li

    págs. 1081-1252

    

  • Translocation of AT~1- and AT~2-Receptors by Higher Concentrations of Angiotensin II in the Smooth Muscle Cells of Rat Internal Anal Sphincter

    M. A. F. de Godoy

    págs. 1088-1103

    

  • Prostaglandin E~2 Receptor EP4 Contributes to Inflammatory Pain Hypersensitivity

    C.-R. Lin, L. Barrett, F. Amaya

    págs. 1096-1123

    

  • Mast Cell Stabilizer Ketotifen [4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one Fumarate] Prevents Mucosal Mast Cell Hyperplasia and Intestinal Dysmotility in Experimental Trichinella spiralis Inflammation in the Rat

    Patri Vergara, M. Porras, H. Serna

    págs. 1104-1111

    

  • Muscarinic Regulation of Ether-a-go-go-Related Gene K^+ Currents in Interstitial Cells of Cajal

    C. M. McKay, J. D. Huizinga

    págs. 1112-1264

    

  • Estrogenic Agonist Activity of ICI 182,780 (Faslodex) in Hippocampal Neurons: Implications for Basic Science Understanding of Estrogen Signaling and Development of Estrogen Modulators with a Dual Therapeutic Profile

    L. Zhao, R. D. Brinton, K. O Neill

    págs. 1124-1132

    

  • Studies to Investigate the in Vivo Therapeutic Window of the gamma-Secretase Inhibitor N^2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N^1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 Mouse

    N. A. McHugh, L. A. Hyde

    págs. 1133-1171

    

  • Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic Effects

    M. L. Schwartzman, S. J. Peterson, Adam L. Kruger

    págs. 1144-1199

    

  • Pifithrin-alpha Enhances Chemosensitivity by a p38 Mitogen-Activated Protein Kinase-Dependent Modulation of the Eukaryotic Initiation Factor 4E in Malignant Cholangiocytes

    R. Henson, H. Wehbe

    págs. 1153-1458

    

  • Differentiation-Specific Factors Modulate Epidermal CYP1-4 Gene Expression in Human Skin in Response to Retinoic Acid and Classic Aryl Hydrocarbon Receptor Ligands

    D. S. Keeney, M. M. Neis, P. A. Ladd, L. Du

    págs. 1162-1190

    

  • Discovery of Novel Hippocampal Neurogenic Agents by Using an in Vivo Stable Isotope Labeling Technique

    M. Shankaran

    págs. 1172-1218

    

  • Estradiol Protects against Ethanol-Induced Bone Loss by Inhibiting Up-Regulation of Receptor Activator of Nuclear Factor-kappaB Ligand in Osteoblasts

    M. Hidestrand, J.-R. Chen, R. L. Haley

    págs. 1182-1275

    

  • Modest Inflammation Enhances Diclofenac Hepatotoxicity in Rats: Role of Neutrophils and Bacterial Translocation

    R. F. Stachlewitz, X. Deng

    págs. 1191-1335

    

  • CI-IB-MECA [2-Chloro-N^6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] Reduces Ischemia/Reperfusion Injury in Mice by Activating the A~3 Adenosine Receptor

    L. M. Kreckler, Z.-D. Ge, J. N. Peart

    págs. 1200-1285

    

  • Characterization of Cannabinoid Agonists and Apparent pA~2 Analysis of Cannabinoid Antagonists in Rhesus Monkeys Discriminating Delta^9-Tetrahydrocannabinol

    L. R. McMahon

    pág. 1211

    

  • Oral Treatment with Rofecoxib Reduces Hippocampal Excitotoxic Neurodegeneration

    S. J. Hewett, J. M. Silakova

    págs. 1219-1224

    

  • In 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Primates, the Selective 5-Hydroxytryptamine 1a Agonist (R)-(+)-8-OHDPAT Inhibits Levodopa-Induced Dyskinesia but Only with Increased Motor Disability

    K. Tayarani-Binazir, M. M. Iravani

    págs. 1225-1234

    

  • Effects of Analgesic or Antidepressant Drugs on Pain- or Stress-Evoked Hippocampal and Spinal Neurokinin-1 Receptor and Brain-Derived Neurotrophic Factor Gene Expression in the Rat

    K. E. McCarson, V. Duric

    págs. 1235-1243

    

  • The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at alpha~1 Subunit-Containing GABA~A Receptors

    P. Popik, M. Krawczyk, E. Kostakis

    págs. 1244-1316

    

  • 7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one Is a Novel Competitive and Selective Inhibitor of Dipeptidyl Peptidase IV with an Antihyperglycemic Activity

    K. Yamazaki

    págs. 1253-1257

    

  • Inhalation of Human Insulin Is Associated with Improved Insulin Action Compared with Subcutaneous Injection and Endogenous Secretion in Dogs

    K. M. Stettler, D. S. Edgerton

    pág. 1258