Journal of Pharmacology and Experimental Therapeutics

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  Año 2006, Vol. 316, Número 3

  • Elevation of Endocannabinoid Levels in the Ventrolateral Periaqueductal Grey through Inhibition of Fatty Acid Amide Hydrolase Affects Descending Nociceptive Pathways via Both Cannabinoid Receptor Type 1 and Transient Receptor Potential Vanilloid Type-1 Receptors

    T. Bisogno, V. de Novellis, S. Maione

    págs. 969-1061

    

  • A Trimeric Anti-HER2/neu ScFv and Tumor Necrosis Factor-alpha Fusion Protein Induces HER2/neu Signaling and Facilitates Repair of Injured Epithelia

    S. L. Morrison, T.-H. Huang

    págs. 983-1030

    

  • Molecular Targeting of BCL2 and BCLXL Proteins by Synthetic BCL2 Homology 3 Domain Peptide Enhances the Efficacy of Chemotherapy

    S. S. Dharap

    págs. 992-1158

    

  • Erythropoietin, Modified to Not Stimulate Red Blood Cell Production, Retains Its Cardioprotective Properties

    C. Moon, M. Krawczyk

    págs. 999-1024

    

  • Immunomodulatory Effects of Etanercept in an Experimental Model of Spinal Cord Injury

    T. Genovese

    págs. 1006-1016

    

  • Therapeutic Promise of Proteinase-Activated Receptor-2 Antagonism in Joint Inflammation

    J. C. Lockhart, E. B. Kelso

    págs. 1017-1069

    

  • Estrogen Receptor alpha Mediates Acute Potassium Channel Stimulation in Human Coronary Artery Smooth Muscle Cells

    R. E. White, X. Cui, Shuyi Li, G. Han, S. Zhu, H. Ma, Xiuping Yu, L. Lu

    págs. 1025-1097

    

  • Glibenclamide-Induced Apoptosis Is Specifically Enhanced by Expression of the Sulfonylurea Receptor Isoform SUR1 but Not by Expression of SUR2B or the Mutant SUR1(M1289T)

    A. Hambrock, C. B. de Oliveira Franz

    págs. 1031-1164

    

  • Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury

    A. Nakajima

    págs. 1038-1046

    

  • Effects of Calcium Channel Blockade on Angiotensin II-Induced Peritubular Ischemia in Rats

    T. Yamamoto, H. Kiyomoto, A. Miyatake, N. Kondo

    págs. 1047-1052

    

  • Metformin Prevents Endotoxin-Induced Liver Injury after Partial Hepatectomy

    I. Bergheim, J. P. Luyendyk

    págs. 1053-1237

    

  • Cumulative Activation of Akt and Consequent Inhibition of Glycogen Synthase Kinase-3 by Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor-1 in Cultured Hippocampal Neurons

    N. N. Johnson-Farley

    págs. 1062-1087

    

  • The Phase 2 Enzyme Inducers Ethacrynic Acid, DL-Sulforaphane, and Oltipraz Inhibit Lipopolysaccharide-Induced High-Mobility Group Box 1 Secretion by RAW 264.7 Cells

    M. E. Killeen, J. A. Englert

    págs. 1070-1228

    

  • Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils

    J. P. Luyendyk, J. F. Waring, M. J. Liguori

    págs. 1080-1174

    

  • Ex Vivo Imaging of Fatty Acid Amide Hydrolase Activity and Its Inhibition in the Mouse Brain

    S. T. Glaser, A. N. Gifford, S. J. Gatley

    págs. 1088-1121

    

  • Comparative Evaluation of HERG Currents and QT Intervals following Challenge with Suspected Torsadogenic and Nontorsadogenic Drugs

    A. N. Katchman

    págs. 1098-1106

    

  • The Effect of NCX4016 [2-Acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl Ester] on the Consequences of Ischemia and Reperfusion in the Streptozotocin Diabetic Rat

    S. G. Burke, C. L. Wainwright

    págs. 1107-1114

    

  • The Urotensin-II Receptor Antagonist Palosuran Improves Pancreatic and Renal Function in Diabetic Rats

    M. Clozel

    págs. 1115-1129

    

  • TrkAd5: A Novel Therapeutic Agent for Treatment of Inflammatory Pain and Asthma

    M. S. Fahey, E. van den Worm, J. J. Watson

    págs. 1122-1136

    

  • Fibrin Affinity of Erythrocyte-Coupled Tissue-Type Plasminogen Activators Endures Hemodynamic Forces and Enhances Fibrinolysis in Vivo

    M. S. Goel, K. Ganguly

    págs. 1130-1152

    

  • Advantages for Transdermal over Oral Oxybutynin to Treat Overactive Bladder: Muscarinic Receptor Binding, Plasma Drug Concentration, and Salivary Secretion

    T. Oki, A. Toma-Okura

    págs. 1137-1145

    

  • Brain Cholesterol Synthesis in Mice Is Affected by High Dose of Simvastatin but Not of Pravastatin

    K. M. Rentsch, K. M. Thelen

    págs. 1146-1334

    

  • Angiotensin I-Converting Enzyme Inhibitors Block Protein Kinase Cepsilon by Activating Bradykinin B~1 Receptors in Human Endothelial Cells

    S. Stanisavljevic

    págs. 1153-1268

    

  • A Model of Controlled Acute Hyperglycemia in Rats: Effects of Insulin and Glucagon-Like Peptide-1 Analog

    J. K. Saha

    pág. 1159

    

  • Linopirdine Modulates Calcium Signaling and Stimulus-Secretion Coupling in Adrenal Chromaffin Cells by Targeting M-Type K^+ Channels and Nicotinic Acetylcholine Receptors

    E. V. Dzhura

    págs. 1165-1218

    

  • Modulation of Expression of Rat Mitochondrial 2-Oxoglutarate Carrier in NRK-52E Cells Alters Mitochondrial Transport and Accumulation of Glutathione and Susceptibility to Chemically Induced Apoptosis

    L. H. Matherly, D. A. Putt, Feng Xu

    págs. 1175-1209

    

  • Is the Monkey an Appropriate Animal Model to Examine Drug-Drug Interactions Involving Renal Clearance? Effect of Probenecid on the Renal Elimination of H~2 Receptor Antagonists

    H. Kusuhara, H. Tahara

    págs. 1187-1201

    

  • Comparison of the Antinociceptive Response to Morphine and Morphine-Like Compounds in Male and Female Sprague-Dawley Rats

    J. R. Traynor, E. M. Peckham

    págs. 1195-1290

    

  • Changes in Pharmacokinetics of Anti-HIV Protease Inhibitors during Pregnancy: The Role of CYP3A and P-glycoprotein

    L. Maggio-Price, A. A. Mathias

    págs. 1202-1281

    

  • Relationship between Temperature, Dopaminergic Neurotoxicity, and Plasma Drug Concentrations in Methamphetamine-Treated Squirrel Monkeys

    G. Hatzidimitriou, J. Yuan

    págs. 1210-1385