Journal of Pharmacology and Experimental Therapeutics

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  Año 2005, Vol. 314, Número 1

  • Cancer Prevention: A New Era beyond Cycloxygenase-2

    B. Rigas, K. Kashfi

    págs. 1-8

    

  • Dynamic Association of Nitric Oxide Downstream Signaling Molecules with Endothelial Caveolin-1 in Rat Aorta

    A. E. Linder, L. P. McCluskey

    págs. 9-15

    

  • Prolonged Positive Modulation of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Induces Calpain-Mediated PSD-95/Dlg/ZO-1 Protein Degradation and AMPA Receptor Down-Regulation in Cultured Hippocampal Slices

    H. Jourdi

    págs. 16-26

    

  • Cyclooxygenase-2 Inhibitor SC-236 [4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] Benzenesulfonamide] Suppresses Nuclear Factor-kappaB Activation and Phosphorylation of p38 Mitogen-Activated Protein Kinase, Extracellular Signal-Regulated Kinase, and c-Jun N-Terminal Kinase in Human Mast Cell Line Cells

    S.-J. Kim, H.-J. Jeong

    págs. 27-34

    

  • YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Inhibits Endothelial Cell Functions Induced by Angiogenic Factors in Vitro and Angiogenesis in Vivo Models

    S.-W. Wang, Y.-L. Chang, C.-Y. Peng, F.-C. Cheng, S.-L. Pan, J.-H. Guh, J.-H. Chang

    págs. 35-42

    

  • Characterization of the Formation and Localization of Sulfamethoxazole and Dapsone-Associated Drug-Protein Adducts in Human Epidermal Keratinocytes

    S. Roychowdhury

    págs. 43-52

    

  • Protective Mechanisms of a Metalloporphyrinic Peroxynitrite Decomposition Catalyst, WW85, in Rat Cardiac Transplants

    G. M. Pieper, V. Nilakantan

    págs. 53-60

    

  • Protein Kinase Cepsilon Regulates Tumor Necrosis Factor-alpha-Induced Stannin Gene Expression

    C. Davidson, M. L. Billingsley, B. E. Reese

    págs. 61-69

    

  • Inhibition of Ribonucleotide Reductase Reduces Neointimal Formation following Balloon Injury

    P. N. Kearns, J. C. Henry, M. M. Bonar

    págs. 70-76

    

  • Beneficial Effects of a New 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, TS-011 [N-(3-Chloro-4-morpholin-4-yl) Phenyl-N'-hydroxyimido Formamide], on Hemorrhagic and Ischemic Strokes

    N. Miyata

    págs. 77-85

    

  • Modulation of Protein Tyrosine Phosphatase Activity Alters the Subunit Assembly in Native N-Methyl-D-aspartate Receptor Complex

    K. Ferrani-Kile

    págs. 86-93

    

  • Effects of Azumolene on Ca^2^+ Sparks in Skeletal Muscle Fibers

    G. G. Rodney, Y. Zhang, M. F. Schneider

    págs. 94-102

    

  • In Situ Naphthalene Bioactivation and Nasal Airflow Cause Region-Specific Injury Patterns in the Nasal Mucosa of Rats Exposed to Naphthalene by Inhalation

    M. G. Lee, A. Phimister

    págs. 103-110

    

  • Role of Transient Receptor Potential Vanilloid 1 Receptors in Adjuvant-Induced Chronic Arthritis: In Vivo Study Using Gene-Deficient Mice

    A. Szabo, Z. Helyes, K. Sandor

    págs. 111-119

    

  • The Ratio of Constitutive Androstane Receptor to Pregnane X Receptor Determines the Activity of Guggulsterone against the Cyp2b10 Promoter

    J. L. Staudinger, Xunshan Ding

    págs. 120-127

    

  • Heme-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic alpha-Subunit of the Eukaryotic Initiation Factor Kinase?

    X.-M. Han

    págs. 128-138

    

  • Regulation of Extracellular Glutamate in the Prefrontal Cortex: Focus on the Cystine Glutamate Exchanger and Group I Metabotropic Glutamate Receptors

    R. I. Melendez, P. W. Kalivas, J. Vuthiganon

    págs. 139-147

    

  • D1 Dopamine Receptors Modulate DeltaFosB Induction in Rat Striatum after Intermittent Morphine Administration

    E. M. Unterwald, D. L. Muller

    págs. 148-154

    

  • A Novel Inhibitor of N-Ethylmaleimide-Sensitive Factor Decreases Leukocyte Trafficking and Peritonitis

    C. N. Morrell, K. Matsushita, C. J. Lowenstein

    págs. 155-161

    

  • The Role of Dopamine in a Model of Trigeminovascular Nociception

    P. J. Goadsby, S. Akerman

    págs. 162-169

    

  • Discriminative Stimulus Effects of gamma-Hydroxybutyrate (GHB) in Rats Discriminating GHB from Baclofen and Diazepam

    L. P. Carter, W. Koek

    págs. 170-179

    

  • CYP3A4 Substrate Selection and Substitution in the Prediction of Potential Drug-Drug Interactions

    A. Galetin

    págs. 180-190

    

  • Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes

    P. B. Jacobson, T. W. von Geldern

    págs. 191-200

    

  • Acute and Chronic Corticotropin-Releasing Factor 1 Receptor Blockade Inhibits Cocaine-Induced Dopamine Release: Correlation with Dopamine Neuron Activity

    D. J. Lodge, A. A. Grace

    págs. 201-206

    

  • BAY 41-2272 [5-Cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-Induced Dilation in Ovine Pulmonary Artery: Role of Sodium Pump

    D. U. Bawankule, K. Sathishkumar

    págs. 207-213

    

  • Stress Impairs Murine Intestinal Barrier Function: Improvement by Glucagon-Like Peptide-2

    H. L. Cameron, M. H. Perdue

    págs. 214-220

    

  • Interactions between delta and mu Opioid Agonists in Assays of Schedule-Controlled Responding, Thermal Nociception, Drug Self-Administration, and Drug versus Food Choice in Rhesus Monkeys: Studies with SNC80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Heroin

    G. W. Stevenson

    págs. 221-231

    

  • Inhibition of Platelet Functions and Thrombosis through Selective or Nonselective Inhibition of the Platelet P2 Receptors with Increasing Doses of NF449 [4,4',4",4-(Carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))-tetrakis-benzene-1,3-disulfonic Acid Octasodium Salt]

    S. Magnenat, B. Hechler, M. L. Zighetti

    págs. 232-243

    

  • Inhibitory Effect of the 4-Aminotetrahydroquinoline Derivatives, Selective Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cell Antagonists, on Eosinophil Migration Induced by Prostaglandin D~2

    T. Ikemura, H. Mimura

    págs. 244-251

    

  • A Novel Neurotrophic Agent, T-817MA [1-{3-[2-(1-Benzothiophen-5-yl) Ethoxy] Propyl}-3-azetidinol Maleate], Attenuates Amyloid-beta-Induced Neurotoxicity and Promotes Neurite Outgrowth in Rat Cultured Central Nervous System Neurons

    H. Yamaguchi, K. Hirata

    págs. 252-259