Resumen de A theoretical study of the stereochemical course of the acid cyclization of two 5-oxogermacren- 6,12-olides epimeric in c4
Victor Hugo Kesternich Martinez, Carlos Contreras Ortega, Rolando Martínez
- español
Se ha realizado el análisis conformacional y el estudio teórico del curso estereoquímico de las ciclaciones ácidas de dos germacranolidas epiméricas en C4, empleando el programa MM2 de HyperChem 4.5. La esteroquímica deducida de los productos de reacción, 5-hydroxyguaian-6,12-olides, son plenamente concordante con los resultados experimentales reportados previamente. Tanto el principio de Curtin-Hammet como el postulado de Hammond, permiten proponer una explicación a los resultados obtenidos
- English
The theoretical study of both the conformational distribution and the acid cyclization of two epimeric 5-oxogermacren-6,12-olides in C4 is described. Our results on the stereochemistry of the cyclization products, 5-hydroxyguaian-6,12-olides, agree with experimental results reported previously. Curtin-Hammet principle and Hammond postulate are used to propose reaction pathways consistent with above results. The theoretical results were obtained by using a MM2 program from HyperChem 4.5
