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Resumen de Synthesis and structural characterization of n-benzoyl-tryptamine and its new analogue n-salicyloyltryptamine, a potential anticonvulsant agent

Francisco De Assis Oliveira, Davi Antas e Silva, Lucindo José Quintans-júnior, Stanley Juan Chavez Gutierrez, Reinaldo Nóbrega de Almeida, José Maria Barbosa Filho, Maria de Fátima Vanderlei de Souza

  • N-Benzoyltryptamine (3), previously isolated from Myrtopsis myrtoidea and a new analogue, N-salicyloyltryptamine (5), were prepared by coupling tryptamine with benzoylchloride and methyl salicylate, respectively. Their structural elucidation was made by the usual spectroscopic methods and two-dimentional NMR techniques COSY, COBY and HMBC. N-salicyloyltryptamine (5) was submitted to pharmacological screening behavior, showing depressant effects


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