Synthesis and structural characterization of n-benzoyl-tryptamine and its new analogue n-salicyloyltryptamine, a potential anticonvulsant agent

• FRANCISCO DE ASSIS OLIVEIRA ^[1] ; DAVI ANTAS E SILVA ^[1] ; LUCINDO JOSÉ QUINTANS-JÚNIOR ^[1] ; STANLEY JUAN CHAVEZ GUTIERREZ ^[1] ; REINALDO NÓBREGA DE ALMEIDA ^[1] ; JOSÉ MARIA BARBOSA-FILHO ^[1] ; MARIA DE FÁTIMA VANDERLEI DE SOUZA ^[1]
  1. [1] Universidade Federal da Paraíba

     Universidade Federal da Paraíba

     Brasil

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 51, Nº. 2, 2006, págs. 919-922
• Idioma: inglés
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• Resumen

  • N-Benzoyltryptamine (3), previously isolated from Myrtopsis myrtoidea and a new analogue, N-salicyloyltryptamine (5), were prepared by coupling tryptamine with benzoylchloride and methyl salicylate, respectively. Their structural elucidation was made by the usual spectroscopic methods and two-dimentional NMR techniques COSY, COBY and HMBC. N-salicyloyltryptamine (5) was submitted to pharmacological screening behavior, showing depressant effects