Resumen de Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review

Gisela Camolesi, Karem Lopez Ortega, Janaina Braga Medina, Luana Campos, Alejandro Ismael Lorenzo Pouso, Pilar Gándara Vila, Mario Pérez-Sayáns

• to systematically review the literature, comparing the healing of osteoradionecrosis (ORN) among the therapeutic alternatives: surgical, pharmacological and combined.

  The review was organized according to the PRISMA protocol with regards to the following PICO question: patients with ORN of the jaws (P=Patient); all interventions reported (I = intervention); between all therapies (C=Comparison); healing of lesions (O=outcome).

  Surgical treatment was the most common choice (46.3%) followed by pharmacological treatment, exclusively (25.9%) or combined (26.9%). Treatment exclusively by surgical intervention seems to be most effective option, with 51.2% of the lesions healed, OR for healing of 5.7 (CI95% 1.9-16.9, p=0.002). Only 1 case (0.9%) corresponded to low level laser therapy.

  It seems clear that early intervention with conservative surgical combined with pharmacological methods improves the prognosis of ORN.