Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review

• Gisela CV Camolesi ^[1] ; Karem L. Ortega ^[1] ; Janaina Braga Medina ^[1] ; Luana Campos ^[3] ; Alejandro I Lorenzo Pouso ^[2] ; Pilar Gándara Vila ^[2] ; Mario Pérez Sayáns ^[2]
  1. [1] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
  2. [2] Universidade de Santiago de Compostela

     Universidade de Santiago de Compostela

     Santiago de Compostela, España

     
  3. [3] PhD, DDS. Department of Post-graduation in Implantology, University of Santo Amaro, School of Dentistry. SaÞo Paulo, Brazil; Oral medicine, Brazilian Cancer Control Institute. São Paulo, Brazil

  Mostrar afiliaciones +
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 26, Nº. 2 (March), 2021
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • to systematically review the literature, comparing the healing of osteoradionecrosis (ORN) among the therapeutic alternatives: surgical, pharmacological and combined.

    The review was organized according to the PRISMA protocol with regards to the following PICO question: patients with ORN of the jaws (P=Patient); all interventions reported (I = intervention); between all therapies (C=Comparison); healing of lesions (O=outcome).

    Surgical treatment was the most common choice (46.3%) followed by pharmacological treatment, exclusively (25.9%) or combined (26.9%). Treatment exclusively by surgical intervention seems to be most effective option, with 51.2% of the lesions healed, OR for healing of 5.7 (CI95% 1.9-16.9, p=0.002). Only 1 case (0.9%) corresponded to low level laser therapy.

    It seems clear that early intervention with conservative surgical combined with pharmacological methods improves the prognosis of ORN.