Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review

• Samuel Raimundo Fernandes ^[1] ; Cilénia Baldaia ^[1] ; Hugo Pinto Marques ^[2] ; Francisco Tortosa ^[1] ; Fernando Ramalho ^[1]
  1. [1] Centro Hospitalar Lisboa Norte

     Centro Hospitalar Lisboa Norte

     Socorro, Portugal

     
  2. [2] Centro Hospitalar Lisboa Central. Portugal
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 109, Nº. 5, 2017, págs. 382-385
• Idioma: inglés
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• Resumen

  • Clear-cell cholangiocarcinoma is a very uncommon variant of cholangiocarcinoma with a largely unknown natural history and prognosis. We report a case of a 51-year-old previously healthy woman presenting with a large liver nodule found on routine imaging. Needle biopsy of the lesion suggested a non-hepatocellular carcinoma. After extensive workup for other primary neoplasms, the patient underwent a partial hepatectomy. Histopathology was compatible with a moderately differentiated clear-cell cholangiocarcinoma. There was no evidence of liver disease in the remaining tissue. The patient underwent chemotherapy and remains in clinical remission after two years.