Severe ischemic colitis following olanzapine use: A case report

• Samuel Raimundo Fernandes ^[1] ; Rosa Alves ^[2] ; Luís Araújo Correia ^[1] ; Ana Rita Gonçalves ^[1] ; João Malaquias ^[1] ; Emília Oliveira ^[1] ; José Velosa ^[1]
  1. [1] Centro Hospitalar Lisboa Norte

     Centro Hospitalar Lisboa Norte

     Socorro, Portugal

     
  2. [2] Hospital Garcia de Orta

     Hospital Garcia de Orta

     Almada, Portugal

     
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 108, Nº. 9, 2016, págs. 595-598
• Idioma: inglés
• Enlaces
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• Resumen

  • Ischemic colitis is the most common subtype of intestinal ischemia usually resulting from vasospasm, vessel occlusion or mesenteric hypoperfusion. Neuroleptics have seldom been linked to ischemic colitis by blocking peripheral anticholinergic and antiserotonergic receptors inducing severe gastrointestinal paresis. We report a young patient with severe ischemic colitis requiring surgery due to necrosis of the bowel. After exclusion of other potential causes, olanzapine was admitted as the cause of ischemia. Clinicians should be aware of how to recognize and treat the potentially life-threatening effects of neuroleptics.