Chapter Fifteen - Nucleosides and Nucleotides for the Treatment of Viral Diseases

• Autores: Michael J. Sofia
• Localización: Annual reports in medicinal chemistry, ISSN 0065-7743, Vol 49, 2014, págs. 221-247
• Idioma: inglés
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• Resumen

  • Abstract Nucleosides and nucleotides have played an important role in the treatment of viral diseases. The treatment of human immunodeficiency virus (HIV) infection has seen the introduction of no less than eight nucleos(t)ides into clinical practice where they have become the cornerstone of combination therapies. Nucleos(t)ides have become the standard of care for the treatment of hepatitis B virus (HBV) infection and are rapidly emerging as the backbone of future combination regimens for the treatment of hepatitis C virus (HCV) infection. The treatment of many other viral infections such as those caused by cytomegalovirus, herpes simplex virus, Epstein–Barr virus, and varicella zoster virus rely heavily on nucleos(t)ide-based therapies. Consequently, because of the broad utility and success of these molecules in the treatment of viral diseases, efforts continue to search for novel nucleos(t)ides that can have an impact in antiviral clinical practice. This review will focus on recent developments in the field of nucleos(t)ide antiviral drug discovery and development with emphasis on HIV, HBV, HCV, and Dengue virus.