Publication: Características clínico-microbiológicas de las lesiones cutáneas en el paciente séptico
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2023-04-25
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Universidad Complutense de Madrid
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Abstract
La sepsis constituye una de las primeras causas de mortalidad en el mundo. El principal reto es su diagnóstico precoz. Aunque clínicamente la sepsis exhibe una amplia variedad de signos, las manifestaciones cutáneas han sido pobremente documentadas en la literatura. En dermatología la sepsis impacta en varios aspectos: por un lado, como tejido potencialmente afectado en el transcurso de las consecuencias inflamatorias y/o hemodinámicas de la sepsis y, por otro, al considerarse un órgano capaz de albergar el foco infeccioso inicial o sufrir la extensión metastásica de la infección desde otros órganos. A pesar de ello, en la literatura actual no existe información detallada y actualizada sobre la verdadera prevalencia de las manifestaciones cutáneas en los pacientes con diagnóstico de sepsis, más allá de series de casos o descripciones aisladas de cuadros clínicos o microorganismos concretos. Esta carencia dificulta la interpretación de los hallazgos comúnmente observables en la práctica clínica diaria e impide definir el impacto del compromiso cutáneo en la evaluación pronóstica del paciente séptico...
Sepsis is one of the leading causes of mortality in the world. The main challenge is its early diagnosis. Although clinically sepsis exhibits a wide variety of signs, cutaneous manifestations have been poorly documented in the literature. In dermatology, sepsis has an impact on several aspects: firstly, as a potentially affected tissue in the course of the inflammatory and/or hemodynamic consequences of sepsis and, secondly, as an organ capable of harboring the initial infectious focus or suffering the metastatic spread of the infection from other organs. Despite this, the current literature lacks detailed and updated information on the true prevalence of cutaneous manifestations in patients diagnosed with sepsis, beyond case series or isolated descriptions of clinical pictures or specific microorganisms. This scarcity of information makes it difficult to interpret the findings commonly observed in daily clinical practice and prevents us from defining the impact of cutaneous involvement in the prognostic evaluation of the septic patient...
Sepsis is one of the leading causes of mortality in the world. The main challenge is its early diagnosis. Although clinically sepsis exhibits a wide variety of signs, cutaneous manifestations have been poorly documented in the literature. In dermatology, sepsis has an impact on several aspects: firstly, as a potentially affected tissue in the course of the inflammatory and/or hemodynamic consequences of sepsis and, secondly, as an organ capable of harboring the initial infectious focus or suffering the metastatic spread of the infection from other organs. Despite this, the current literature lacks detailed and updated information on the true prevalence of cutaneous manifestations in patients diagnosed with sepsis, beyond case series or isolated descriptions of clinical pictures or specific microorganisms. This scarcity of information makes it difficult to interpret the findings commonly observed in daily clinical practice and prevents us from defining the impact of cutaneous involvement in the prognostic evaluation of the septic patient...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 08-03-2022