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Long non-coding RNAs involved in different steps of cancer metastasis

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Abstract

Non-proteincoding transcripts bearing 200 base pairs known as long non-coding RNAs (lncRNAs) play a role in a variety of molecular mechanisms, including cell differentiation, apoptosis and metastasis. Previous studies have suggested that frequently dysregulated lncRNAs play a crucial role in various aspects of cancer metastasis. Metastasis is the main leading cause of death in cancer. The role of lncRNAs in different stages of metastasis is the subject of this review. Based on in vitro and in vivo investigations on metastasis, we categorized lncRNAs into distinct stages of metastasis including angiogenesis, invasion, intravasation, survival in circulation, and extravasation. The involvement of lncRNAs in angiogenesis and invasion has been extensively studied. Here, we comprehensively discuss the role and functions of these lncRNAs with a particular focus on the molecular mechanisms.

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Acknowledgements

We acknowledge the Central University of Punjab for providing infrastructure and facilities. Indian Council of Medical Research (ICMR), New Delhi, is acknowledged for Research Associateship 2019-4834/CMB-BMS to P.S. Council of Scientific and Industrial Research (CSIR), New Delhi, IS acknowledged for Senior Research Fellowship (SRF) to Y. C. and P. K. for PhD. Declarations. DST-FIST grant (SR/FST/LS-I/2017/49) to the Department of Human Genetics and Molecular Medicine, Central University of Punjab, is acknowledged with thanks.

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  1. P. Suman, Y. Chhichholiya, and P. Kaur contributed equally.

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  1. Department of Human Genetics and Molecular Medicine, Central University of Punjab Bathinda, Bathinda, Punjab, India

    P. Suman, Y. Chhichholiya, P. Kaur, S. Ghosh & A. Munshi

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PS, YC, PK, and AM conceptualized the idea of the review. PS, YC and PK curated the data. PS, YC, PK and SG prepared and created the draft. AM critically revised and edited the manuscript.

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Correspondence to A. Munshi.

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Suman, P., Chhichholiya, Y., Kaur, P. et al. Long non-coding RNAs involved in different steps of cancer metastasis. Clin Transl Oncol 24, 997–1013 (2022). https://doi.org/10.1007/s12094-021-02761-z

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