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Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects

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Abstract

Huntington disease (HD) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein huntingtin (HTT). Huntingtin-associated protein 1 (HAP1) is the first protein identified as an interacting partner of huntingtin, which is directly associated with HD. HAP1 is mainly expressed in the nervous system and is also found in the endocrine system and digestive system, and then involves in the occurrence of the related endocrine diseases, digestive system diseases, and cancer. Understanding the function of HAP1 could help elucidate the pathogenesis that HTT plays in the disease process. Therefore, this article attempts to summarize the latest research progress of the role of HAP1 and its application for diseases in recent years, aiming to clarify the functions of HAP1 and its interacting proteins, and provide new research ideas and new therapeutic targets for the treatment of cancer and related diseases.

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  1. Xue Zhao and Ai Chen have contributed equally to this work.

Authors and Affiliations

  1. School of Medical Laboratory, Weifang Medical University, Weifang, Shandong, 261053, People’s Republic of China

    X. Zhao, A. Chen, Z. Wang & Xiao-Han Xu

  2. Department of Central Lab, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University. Weihai, Shandong, 264200, People’s Republic of China

    A. Chen

  3. Department of Laboratory Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, 261031, People’s Republic of China

    Y. Tao

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  1. X. Zhao
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Contributions

YT and AC: established the original concept and design. AC, XZ, ZW, and XX: conducted literature retrieval and data analysis. XZ and AC: wrote the manuscript, designed the figures, and made critical revisions to the manuscript. ZW and XX: helped with the discussion and corrected the text. All authors read and approved the final draft.

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Correspondence to Y. Tao.

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Zhao, X., Chen, A., Wang, Z. et al. Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects. Clin Transl Oncol 24, 203–214 (2022). https://doi.org/10.1007/s12094-021-02702-w

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