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Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine

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Abstract

Although caloric restriction (CR) apparently has beneficial effects on the immune system, its effects on the immunological function of the intestinal mucosa are little known. The present study explored the effect of CR on the innate and adaptive intestinal immunity of mice. Balb/c mice were either fed ad libitum (control) or on alternate days fed ad libitum and fasted (caloric restriction). After 4 months, an evaluation was made of IgA levels in the ileum, the gene expression for IgA and its receptor (pIgR), as well as the expression of two antimicrobial enzymes (lysozyme and phospholipase A2) and several cytokines of the intestinal mucosa. CR increased the gene expression of lysozyme and phospholipase A2. The levels of IgA were diminished in the ileum, which apparently was a consequence of the reduced transport of IgA by pIgR. In ileum, CR increased the gene expression for most cytokines, both pro- and anti-inflammatory. Hence, CR differentially modified the expression of innate and adaptive immunity mediators in the intestine.

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Acknowledgements

We thank Bruce Allan Larsen for reviewing the use of English in this manuscript. This work was supported in part by grants from SEPI-IPN. Suarez-Souto MA and Maria Viloria received a scholarship from Conacyt, México. Dominguez Lopez ML, Campos-Rodriguez R, Miliar-Garcia A are fellows of COFAA and SIP-IPN. None of the authors has any conflict of interest in relation to the subjects mentioned or techniques utilized in this manuscript.

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Authors and Affiliations

  1. Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala s/n, CP 11340, Mexico City, DF, México

    María Antonieta Suárez-Souto & María Lilia Domínguez-López

  2. Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, CP 11340, Mexico City, DF, México

    Eleazar Lara-Padilla, Humberto Reyna-Garfias, María Viloria, Pedro López-Sánchez, Ángel Miliar-García, Alexander Kormanovski & Rafael Campos-Rodríguez

  3. Departamento de Microbiología, UBIPRO, FES-Iztacala, UNAM, Avenida de los Barrios s/n, CP. 54090, Tlalnepantla Edo. de México, México

    Víctor Rivera-Aguilar

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  1. María Antonieta Suárez-Souto
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Correspondence to Rafael Campos-Rodríguez.

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Suárez-Souto, M.A., Lara-Padilla, E., Reyna-Garfias, H. et al. Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine. J Physiol Biochem 68, 163–173 (2012). https://doi.org/10.1007/s13105-011-0128-9

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