Resumen de La disfunción endotelial como causa de hipoacusia neurosensorial

María Grazia Foglia Fernández

• This study provides a baseline data description of 117 individuals, a prospective approach and a therapeutical performance analysis of 83 individuals with cardiovascular risk factors in order to establish the strength of association of hearing with endothelial function. The main objective is to study the association of the auditory function of patients with high cardiovascular risk with the endothelial function and the arterial stiffness, measured at small arteries, before and after one-year lifestyle intervention. The most relevant conclusions of the study are: 1. A major arterial stiffness and therefore a high increase rate corresponds with a worst hearing function. 2. The endothelial function measured by the hyperaemic reactivity rate shows no relationship with the auditory function. 3. Changes in lifestyle for a year did not contribute to improve neither the vascular risk factors nor the vascular function parameters and therefore no hearing function improvement was observed. 4. Patients with cardiovascular risk factors have worse hearing function than individuals without risk factors. 5.The alteration of the hearing function is associated in a statistically significant way to the presence of hipertriglyceridemia, high abdominal circumference and high ApoB levels. 1. In this study hearing loss was directly associated to the increase of E-selectin, showing no relationship with other biochemical parameters of oxidative stress, inflammation and endothelial dysfunction. 2. Arterial stiffness and abdominal circumference were the main determinants of auditory function.