NMR and molecular recognition: the interaction of human galectin-8 and DC-SIGN with natural glycans and glycomimetics

• Autores: Marcos Javier Gomez Redondo
• Directores de la Tesis: Jesús Jiménez Barbero (dir. tes.), Ana Ardá Freire (dir. tes.), Maria Esther Lete Exposito (tut. tes.)
• Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2023
• Idioma: inglés
• Programa de doctorado: Programa de Doctorado en Química Sintética e Industrial por la Universidad del País Vasco/Euskal Herriko Unibertsitatea y la Universidad Pública de Navarra
• Materias:
  • Química
    • Química analítica
      • Espectroscopia de resonancia magnética
    • Bioquímica
      • Glúcidos
      • Proteínas
• Enlaces
  • Tesis en acceso abierto en: ADDI
• Resumen

  • Glycans are everywhere in Nature, where they play a plethora of functions in every domain of life. The recognition of glycans by lectins is at the heart of a myriad of biological proceses, including host-pathogen interactions, which have made them essential targets in the field of drug discovery. In this context, the main focus of this Thesis has centred on unravelling of the conformational and structural properties of the recognition of a battery of natural and synthetically obtained glycans to two specific human lectins, galectin-8 and DC-SIGN. This analysis has been performed employing a synergic combination of NMR-based methods, assisted by other experimental methods (ITC) and computational tools (Molecular Dynamics simulations).