Fenómeno de acomodación inmunológica: Trasplante hepático ABO incompatible. Caso clínico

• Lorena Castro ^[2] ; Andrés Yarur ^[2] ; Roberto Segovia ^[2] ; Rodrigo Ponce ^[2] ; Mario Uribe ^[1] ; Mario Ferrario ^[1] ; Erwin Buckel ^[1] ; Hernán Iturriaga ^[2]
  1. [1] Clínica Las Condes

     Clínica Las Condes

     Santiago, Chile

     
  2. [2] Hospital San Borja-Arriarán Departamento de Medicina
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 137, Nº. 8, 2009, págs. 1061-1065
• Idioma: español
• Títulos paralelos:
  • Accomodation process: ABO-incompatible liver transplantation. Report of one case
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• Resumen

  • We report a 33 year-old female with a diagnosis of halothane-induce fulminant hepatic failure who was subjected to a liver transplant with an ABO-incompatible graft. The patient received a therapeutic protocol that included total plasma exchange, splenectomy and quadruple immunosuppression. After 5 years, the patient remains asymptomatic and with normal liver enzymes, while she has been treated with low dose of immunosuppressive drugs. This case demonstrates an example of how the immunological process of accomodation opens the possibility of using ABO-incompatible organs as a definitive grafts.