Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos

• Carolina Ibáñez C ^[1] ; Marcelo Garrido S ^[1] ; Lidia Medina ^[1] ; Sumie Kato ^[1] ; María Loreto Bravo ^[1] ; Pamela González ^[1] ; Barbara Oliva ^[1] ; Javier Pizarro ^[2] ; Eva Bustamante ^[3] ; Jorge Brañes ^[1] ; Mauricio Cuello ^[1] ; Gareth I Owen ^[1]
  1. [1] Pontificia Universidad Católica de Chile

     Pontificia Universidad Católica de Chile

     Santiago, Chile

     
  2. [2] Hospital Sotero del Río
  3. [3] Fundación Arturo López Pérez

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 141, Nº. 5, 2013, págs. 669-673
• Idioma: español
• Títulos paralelos:
  • In vitro cell response to chemotherapeutic agents, to personalize ovarian cancer treatment: Report of two cases
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• Resumen

  • Our laboratory has implemented an in vitro assay to estimate the response to chemotherapy in ovarian cancer cells pertaining to individual patients. In two selected patients, we determined the correlation between an in vitro assay of cells from suspected ovarian cancer ascites, with the clinical chemotherapy response. Cancer cells isolated from peritoneal fluid with suspected ovarian cancer were tested for cytotoxicity with corresponding chemotherapy regimens. Circulating Cal25 levels and attending physician consultation determined clinical course and response to chemotherapy. The in vitro assay result correlated with Cal25 levels, progression free survival and attending physician evaluation. The assay predicted correctly the failure of two successive chemotherapy regimes in the first patient, while predicting a favorable clinical response in the second subject.