Aumento de interleuquinas proinflamatorias y de cortisol plasmático en bronquiolitis por virus respiratorio sincicial: relación con la gravedad de la infección

• Patricia V Díaz ^[1] ; Aldo A Gaggero ^[1] ; Ricardo A Pinto ^[1] ; Rossana Mamani ^[1] ; Paola A Uasapud ^[2] ; María Rosa Bono ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Servicio de Salud Metropolitano Norte Centro de Salud Familiar Agustín Cruz Melo
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 141, Nº. 5, 2013, págs. 574-581
• Idioma: español
• Títulos paralelos:
  • Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis
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• Resumen

  • Background: An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection. Aim: To quantify pro-inflammatory cytokines (IL-6-IL-8, ÍL-2-P and TNF-a) in nasopharyngeal aspirate (NPA) and plasma, and plasma cortisol in previously healthy infants with RSV bronchiolitis. Patients and Methods: We studied 49 infants aged less than one year of age with RSV bronchiolitis and 25 healthy controls. Severity was defined using a previously described modified score. We quantified interleukins in NPA and plasma by flow cytometry and plasma cortisol by radioimmunoanalysis. Results: Among patients with RSV bronchiolitis, 25 were classified as severe and 24 as moderate or mild. Significantly higher levels ofIL-6 and IL-8 in NPA and plasma and IL-lfi in NPA were found in children classified as severe, when compared to those with moderate or mild disease and controls. There was a positive correlation between IL-6 and cortisol in plasma (r = 0,55; p < 0,0001) and both were correlated with the severity of the disease. Conclusions: RSV bronchiolitis severity was associated with higher levéis of inflammatory interleukins and plasma cortisol.