Resumen de Synthesis, characterization and in vitro antifungal evaluation of novel benzimidazo[1,2-c]quinazolines

B. A. Insuasty, H. Torres, J. Quiroga, R. Abonía, R. Rodríguez, M. Nogeras, Susana A. Sánchez, C. Saitz, S. L. Alvarez, S. A. Zacchino

• The synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments such as ¹H-COSY, NOESY, DEPT, HSQC and HMBC. These compounds showed antifungal properties only against dermatophytes. Among them, those with electron-donor substituents on the 6-phenyl ring inhibited mainly T. rubrum and E. floccosum with MICs between 25-250 µg/mL and M. canis, M. gypseum and T. mentagrophytes with MICs between 50-250 µg/mL. Structures with electron-withdrawing substituents on the phenyl ring did not show any activities up to 250 µg/ml. Methyl substituents on the benzimidazole ring seem negatively affect the antifungal behaviour of this series