Regio and stereoselective hydroxylation of 5a-hydroxy-14-eudesm-11-en-3-one eudesmane by biotransformation of rhizopus nigricans

• SERGIO ÁGUILA ^[1] ; JULIO ALARCÓN ^[2] ; CAROLINA CONEJEROS ^[2] ; JOEL B ALDERETE ^[1]
  1. [1] Universidad de Concepción

     Universidad de Concepción

     Comuna de Concepción, Chile

     
  2. [2] Universidad del Bío-Bío

     Universidad del Bío-Bío

     Comuna de Concepción, Chile

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 51, Nº. 2, 2006, págs. 855-857
• Idioma: inglés
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• Resumen

  • This paper describes a combined synthesis of b-hydroxy-sesquiterpen eudesmane derivative using a microbiological hydroxylation sesquiterpen eudesmane derivative as the key reaction. The stereochemistry of the biohydroxylation was identified using mono and bi-dimensional ¹H-NMR experiments