¹h and 13c nmr spectral assignments and x-ray crystallography of n-(3-(1h-imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine

• MARCIA PÉREZ-FEHRMANN ^[1] ; VICTOR KESTERNICH ^[1] ; FELIPE VERDUGO ^[1] ; LAURENCE MARCOURT ^[2] ; PHILIPPE CHRISTEN ^[2] ; IVÁN BRITO ^[3]
  1. [1] Universidad Católica del Norte

     Universidad Católica del Norte

     Antofagasta, Chile

     
  2. [2] Université de Genève

     Université de Genève

     Genève, Suiza

     
  3. [3] Universidad de Antofagasta

     Universidad de Antofagasta

     Antofagasta, Chile

     

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 2, 2013, págs. 1771-1774
• Idioma: inglés
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• Resumen

  • N-(3-(1H-Imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine (2) was obtained by nucleophilic substitution of 1-(3-aminopropyl)-imidazole over 4-chloro-2-phenylquinazoline (1) with DMF/TEA at room temperature. The precursor and product were characterized by NMR spectroscopy. The structure of the title compound was confirmed by X-ray diffraction methods. The quinazoline fragment (2) is essentially planar and makes a dihedral angle of 66.35 ° with the imidazole plane. In the crystal packing the molecules are associated by two strong intermolecular NH----N hydrogen bonds with graph-set motif R²2(16). These pairs are linked by two π-π interactions.