Laçasse catalyzed-synthesis of 4,4'-biphenyldiamine from p-chloroaniline. Evaluation of antifungal and antioxidant activities

• ANA M CAMPOS ^[1] ; LEONORA MENDOZA ^[1] ; JUAN VASQUEZ ^[1] ; RICARDO MELO ^[1] ; JENNIFER SALAS ^[1] ; MILENA COTORAS ^[1]
  1. [1] Universidad de Santiago de Chile Facultad de Química y Biología
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 61, Nº. 3, 2016, págs. 3031-3033
• Idioma: inglés
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• Resumen

  • Laccase is a copper-containing oxidase that catalyzes reduction of molecular oxygen to water and the oxidation of a phenolic compound. In this paper, laccase was utilized to synthesize 4,4'-Biphenyldiamine using p-chloroaniline as substrate by means of a coupling reaction. The synthesized compound, 4,4'-Biphenyldiamine, presented low antifungal activity against the phytopathogenic fungus Botrytis cinerea, however the antioxidant ability, measurement by ORAC-PGR method, was higher than substrate. This work corresponds to the first report of synthesis 4,4'-Biphenyldiamine, from p-chloroaniline in a lacasse-catalyzed reaction.