Latent tuberculosis infection in patients with autoimmune diseases treated with Infliximab and Etanercept

• Parra-Lara, Luis Gabriel ^[2] ; Bojorge Ospina, Cindy Johana ^[1] ; Correa Martínez, Daniela ^[1] ; Pino, Jessica ^[2] ; García-Goez, José Fernando ^[3]
  1. [1] Universidad Icesi

     Universidad Icesi

     Colombia

     
  2. [2] Centro de Investigaciones Clínicas (CIC), Fundación Valle del Lili
  3. [3] Universidad Icesi y Infectious Disease Service, Department of Internal Medicine, Fundación Valle del Lili

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• Localización: Infectio: Revista de la Asociación Colombiana de Infectología, ISSN-e 2422-3794, ISSN 0123-9392, Vol. 14, Nº. 1, 2010
• Idioma: inglés
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  • Introduction: Latent tuberculosis infection (LTI) in patients receiving biological therapies is a reality, but this has not been studied in depth in Colombia.Objective: To determine the prevalence of LTI in patients with autoimmune diseases receiving treatment with Infliximab / Etanercept in a referral health center in Cali, Colombia, between the years 2011-2017.Methodology: A retrospective observational study was conducted. We reviewed the ‘Registry of patients exposed to tumor necrosis factor-alpha (TNF-?) antagonist drugs in Fundación Valle del Lili’. Patients diagnosed with a chronic inflammatory disease were included who received treatment with Infliximab, Etanercept, or both and followed at least two years.Design: Retrospective observational study. We reviewed the ‘Registry of patients exposed to tumor necrosis factor alpha (TNF-?) antagonist drugs in Fundación Valle del Lili’. Patients diagnosed with a chronic inflammatory disease were included who received treatment with Infliximab, Etanercept or both and followed at least a period of 2 years.Results: We included 82 patients; the median age was 47.5 years (IQR=28-60 years), 76% were female, 2% had intimate contact with tuberculosis, 15% were older than 65 years. The 56% had a diagnosis of rheumatoid arthritis as an indication of therapy, and 2% presented infection by hepatitis C virus. The median PPD was 12 mm (IQR=10-17 mm). The prevalence was 3.8% for LTI.Conclusion: The conversion to LTI shows an important prevalence, so it is convenient to perform a routine follow-up of patients receiving therapies with Infliximab and Etanercept.