The functional role of circular RNAs in the pathogenesis of retinoblastoma: a new potential biomarker and therapeutic target?

• Mohsen Karami Fath ^[1] ; Sasan Pourbagher Benam ^[7] ; Niloofar Kouhi Esfahani ^[8] ; Negar Shahkarami ^[2] ; Shahriyar Shafa ^[3] ; Hossein Bagheri ^[9] ; Seyyed-Ghavam Shafagh ^[4] ; Zahra Payandeh ^[5] ; Ghasem Barati ^[6]
  1. [1] Kharazmi University

     Kharazmi University

     Irán

     
  2. [2] Fasa University of Medical Sciences

     Fasa University of Medical Sciences

     Irán

     
  3. [3] Kerman University of Medical Sciences

     Kerman University of Medical Sciences

     Irán

     
  4. [4] Iran University of Medical Sciences

     Iran University of Medical Sciences

     Irán

     
  5. [5] Karolinska Institute

     Karolinska Institute

     Suecia

     
  6. [6] Stem Cell Technology Research Center

     Stem Cell Technology Research Center

     Irán

     
  7. [7] Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  8. [8] Faculty of Medicine, Rudn University of Moscow, Moscow, Russia
  9. [9] Faculty of Medicine, Islamic Azad University of Tehran Branch, Tehran, Iran

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 8 (August), 2023, págs. 2350-2364
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as RNAs (coding and non-coding RNAs) are also involved in the progression of the tumor. Circular RNA (circRNA) is the most recently identified RNA and is involved in regulating gene expression mainly through “microRNA sponges”. The dysregulation of circRNAs has been observed in several diseases and tumors. Also, various studies have shown that circRNAs expression is changed in RB tissues. Due to their role in the pathogenesis of the disease, circRNAs might be helpful as a diagnostic or prognostic biomarker in patients with RB. In addition, circRNAs could be a suitable therapeutic target to treat RB in a targeted therapy approach.