Innovative compounds to battle multiresistanceto antibiotics: Use of PVA-tannic acid nanoparticles to inhibit staphylococcus pseudointermedius growth
- Autores: Guillermo Martínez, María Pérez Aranda, Manuel Merinero, Belén Begines Ruíz, Tamara Ortiz, Salvadora Navarro, Raúl Aguilera Velázquez, María Jesús Martín Valero, Ignacio Rodríguez Llorente, Eloísa Pajuelo Domínguez, Ana Paula Zaderenko Partida, Ana Alcudia Cruz
- Localización: Sinergias en la investigación en STEM / coord. por Ana María Beltrán Custodio, Manuel Félix Ángel, 2021, ISBN 978-84-122093-4-1, págs. 45-48
- Idioma: inglés
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Resumen
Antibiotic resistance is an increasing public health problem that affects numerouspathogens, including Staphylococcus pseudintermedius, which has a high prevalenceof methicillin resistance and can be easily transmitted to humans. Nowadays, thescientific community is developing new compounds that not only improve classictherapies in fighting antibiotic resistances but also prevent its appearance, essentialto maintain health protection. The main objective of the present study is tosynthesize tannic acid and polyvinyl alcohol nanoparticles and to determine theirpotential as growth inhibitors for S. pseudintermedius, to be considered a potentialalternative therapy. The study includes diameter and Z-potential measurementsfor nanoparticles characterization and antimicrobial effect assays with differentnanoparticles concentrations. MIC90 is determined as 112 μg/mL. Nonetheless,further studies to identify the underlying action mechanisms of these nanoparticlesare going on in our group.
