Necrotizing enterocolitis in nutritioned neonates parenteral: Risk/protection factors
- Autores: Cristina Mora Herrera, Carmen María Cuadros Martínez, Manuel Jerónimo López Muñoz
- Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 23, Nº. 4, 2021, págs. 226-230
- Idioma: inglés
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Resumen
Introduction: Necrotizing enterocolitis (NEC) is a serious pathology in newborns, increasing hospitalization times and it may require surgery.
Objective: Defining risk/protective factors for NEC in newborns (NB) with parenteral nutrition (PN) and analyze the evolution after the development of this pathology.
Method: Retrospective observational study, NBs admitted to the neonatal ICU with PN, excluding cases of death after being carriers of PN. Variables: sex; gestation week at birth; diagnosis, NEC classification; days and increase in PN contribution; days to incorporate breast milk (BM); systemic steroids; antibiotics, days to gain weight and reach 1,800-2,000 g.
Results: Seventy-two patients were included, who underwent 984 PN by central route, selected from the Kabisoft® program, of which seven developed NEC. The mean gestation weeks at birth was 29.87, with 45.83% being women. The patients remained with PN for 1-22 days, and those who developed NEC had PN for a minimum of 10 days, and an increase in their contribution between 1-4 cc/h, the mean being 1,01 cc/h. With the exception of one patient, they incorporated BM in the first five days of life. In addition, 11.11% received steroids, and none of those developed NEC. Lastly, the mean to gain weight was 4.76 days, and to reach a weight of 1,800-2,000 g an interval of 10-58 days was observed, losing follow-up in two patients; in the case of children with NEC of 24-58 days.
Conclusions: It could be beneficial to identify specific preventive, nutritional and pharmacological strategies that, if administered successfully to the right patients, could reduce the incidence of NEC
