Sensitisation to aeroallergens in Brazilian adolescents living at the periphery of large subtropical urban centres

• A.C. Pastorino ^[3] ; F.C. Kuschnir ^[1] ; L.K.P. Arruda ^[2] ; R.R.D. Casagrande ^[3] ; R.G.L. de Souza ^[3] ; G.A.C. Dias ^[2] ; H.H.N. Silveira ^[2] ; A.J.L.A. da Cunha ^[1] ; C.M.A. Jacob ^[4] ; D. Solé ^[5]
  1. [1] Universidade Federal do Rio de Janeiro

     Universidade Federal do Rio de Janeiro

     Brasil

     
  2. [2] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
  3. [3] Department of Paediatrics. Children's Institute. São Paulo University School of Medicine. São Paulo
  4. [4] Allergy and Immunology Unit. Children's Institute. Department of Paediatrics. São Paulo University School of Medicine. São Paulo
  5. [5] Department of Pediatrics. Federal University of São Paulo-Escola Paulista de Medicina. São Paulo. Brazil

  Mostrar afiliaciones +
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 36, Nº. 1, 2008, págs. 9-16
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Objectives To evaluate the sensitization to aeroallergens determined by skin prick test (SPT) in Brazilian adolescents, and to correlate its positivity with the diagnosis of asthma and/or rhinitis based on the written questionnaire (WQ) of ISAAC phase III study.

    Patients and Methods A total of 996 adolescents (387 boys) were selected by systematic samples. A standard allergen extracts panel (positive/negative control, D pteronyssinus [Dpt], P americana [Pa], B germanica [Bg], dog, cat, fungal and grass mix) was used and its positivity compared with positive responses to asthma, rhinitis or both.

    Results Positive SPT to at least one allergen was observed in 466 adolescents (46.8 %), with sensitization to Dpt in 79.1 %. Positivity to more than one allergen occurred in 232 students (49.8 %). The frequency of positive SPTs was significantly higher among adolescents with asthma (OR=2.16), rhinitis (OR=1.69), and asthma and rhinitis (OR=2.03). Positive SPT to four or more allergens were higher among asthmatics (OR = 2.6) and among adolescents with asthma and rhinitis (OR=3).

    Conclusions A high sensitisation rate to aeroallergens was observed, significantly higher among those with asthma, rhinitis or a combination of both, especially in multiple sensitisations.