Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis: a preliminary study
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Mariana-Sudati Rodrigues [1] ; Eduardo-Oliveira Kaefer [1] ; Juliana-Tomaz Sganzerla [1] ; Humberto-Thomazi Gassen [1] ; Rubem-Beraldo dos Santos [1] ; Sergio-Augusto-Quevedo Miguens-Jr [1]
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[1] Universidade Luterana do Brasil
Universidade Luterana do Brasil
Brasil
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- Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 12, Nº. 10 (October), 2020, págs. 944-950
- Idioma: inglés
- Enlaces
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Resumen
Actinic Cheilitis (AC) is a pathological condition of the labial mucosa considered potentially malignant. The aim of this study was to investigate the effect of treatment of AC with daily use of a vitamin-based barrier cream.
For this clinical study, 36 participants with lower-lip AC were recruited from three oral medicine services. At baseline, participants were evaluated by clinical examination and clinical severity of AC was classified as grade I to IV. All participants were dispensed a tube of a barrier cream containing vitamins A, D, E and ZnO to apply once nightly for 90 consecutive days. Monthly follow-up was performed to reclassify AC clinial severity. The primary outcome of interest was clinical remission of AC at 90-day follow-up compared to baseline.
Progressive remission of AC lesions was observed as early as the first month and throughout the assessment period (p = 0.000). The 3-month period was insufficient for remission of lesions, especially among male participants (p = 0.002) and with a longer sun exposure in years (p = 0.007).
Daily use of the vitamin-based barrier cream had a promissing positive impact on the severity of actinic cheilitis. However, a 90-day course of treatment was not sufficient to achieve lesions remission. The findings of this study suggest a promising new avenue for the treatment of lower-lip AC.
