Oral leukoplakia, a clinical-histopathological study in 412 patients

• Andrea Rubert ^[2] ; Leticia Bagán ^[1] ; Jose V. Bagán ^[3]
  1. [1] Universitat de València

     Universitat de València

     Valencia, España

     
  2. [2] Assistant Professor of Oral Medicine. European University of Valencia
  3. [3] Chairman of Oral Medicine. University of Valencia. Head of the Department of Stomatology and Maxillofacial Surgery University General Hospital. Valencia (Spain) Fundación de Investigación del Hospital General Universitario of Valencia

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• Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 12, Nº. 6 (June), 2020, págs. 540-546
• Idioma: inglés
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• Resumen

  • A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal.

    A study was made of 412 patients with oral leukoplakia, analyzing the corresponding clinical factors and histopathological findings; assessing associations between the different clinical presentations and epithelial dysplasia; and evaluating the factors influencing malignant transformation of the lesions.

    Clinically, homogeneous presentations were seen to predominate (n = 336, 81.6%), while histologically most of the lesions exhibited no dysplastic changes (n = 271; 65.7%). Stage 1 of the van der Waal classification was the most common presentation (n = 214; 51.9%). The lesion malignization rate was 8.3%, and the factors associated to a significantly increased malignization risk were non-homogeneous OL lesions (p=0.00), lesion location in the tongue (p=0.00), and the presence of epithelial dysplasia (p=0.00).

    In our series of patients with oral leukoplakia, malignization was associated to the less common clinical presentations of the disease, i.e., non-homogeneous lesions, and the latter tended to exhibit high grade epithelial dysplasia.