The essay tries to outline, in brief the main differences, along with the main possible intersections, between the Anglo-Saxon field of research labeled as cultural studies and semiotics, as they have been conceived and are nowadays conceived and practiced in the Italian context. Sketching very briefly some concepts, along with some of the epistemological bases on which these two critical practices are founded, the essay tries to discuss moving from structuralism (semiotics) to post-structuralism (CS) as a change in the very conception about what a theory, a methodology, and critical (political) thinking is. What is then needed, therefore, is not so much an (im)possible translation between semiotics and cultural studies, but a reflection and a possible fruitful revision of common concepts, such as that of interpretation and discourse.
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